Literature DB >> 2976880

Molecular organisation of the quinic acid utilization (QUT) gene cluster in Aspergillus nidulans.

A R Hawkins1, H K Lamb, M Smith, J W Keyte, C F Roberts.   

Abstract

The functional integrity of the QUTB gene (encoding quinate dehydrogenase) has been confirmed by transformation of a qutB mutant strain. The DNA sequence of the contiguous genes QUTD (quinate permease), QUTB and QUTG (function unknown) has been determined and analysed, together with that of QUTE (catabolic 3-dehydroquinase). The QUTB sequence shows significant homology with the shikimate dehydrogenase function of the complex AROM locus of Aspergillus nidulans, and with the QA-3 quinate dehydrogenase and QA-1S (repressor) genes of Neurospora crassa. The QUTD gene shows strong homology with the N. crassa QA-Y gene and QUTG with the QA-X gene. QUTD, QUTB, and QUTG, QUTE form two pairs of divergently transcribed genes, and conserved sequence motifs identified in the two common 5' non-coding regions show significant homology with UASGAL and UASQA sequences of the Saccharomyces cerevisiae and N. crassa Gal and QA systems. In addition, conserved 5' sequences homologous to the mammalian CAAT box are noted and a previously unreported conserved 22 nucleotide motif is presented.

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Year:  1988        PMID： 2976880     DOI： 10.1007/bf00337715

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  32 in total

1.  Chemical synthesis of a gene for somatomedin C.

Authors:  B S Sproat; M J Gait
Journal:  Nucleic Acids Res       Date:  1985-04-25       Impact factor: 16.971

2.  Hypothesis about the function of membrane-buried proline residues in transport proteins.

Authors:  C J Brandl; C M Deber
Journal:  Proc Natl Acad Sci U S A       Date:  1986-02       Impact factor: 11.205

Review 3.  Gene organization and regulation in the qa (quinic acid) gene cluster of Neurospora crassa.

Authors:  N H Giles; M E Case; J Baum; R Geever; L Huiet; V Patel; B Tyler
Journal:  Microbiol Rev       Date:  1985-09

4.  A eukaryotic repressor protein, the qa-1S gene product of Neurospora crassa, is homologous to part of the arom multifunctional enzyme.

Authors:  I A Anton; K Duncan; J R Coggins
Journal:  J Mol Biol       Date:  1987-09-20       Impact factor: 5.469

5.  Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3' consensus sequence AAUAAA.

Authors:  C Montell; E F Fisher; M H Caruthers; A J Berk
Journal:  Nature       Date:  1983 Oct 13-19       Impact factor: 49.962

6.  The ovalbumin gene-sequence of putative control regions.

Authors:  C Benoist; K O'Hare; R Breathnach; P Chambon
Journal:  Nucleic Acids Res       Date:  1980-01-11       Impact factor: 16.971

7.  Evidence for an intron-contained sequence required for the splicing of yeast RNA polymerase II transcripts.

Authors:  C J Langford; D Gallwitz
Journal:  Cell       Date:  1983-06       Impact factor: 41.582

8.  Molecular cloning of the 3-phosphoglycerate kinase (PGK) gene from Aspergillus nidulans.

Authors:  J M Clements; C F Roberts
Journal:  Curr Genet       Date:  1985       Impact factor: 3.886

9.  Cloning and characterization of the three enzyme structural genes QUTB, QUTC and QUTE from the quinic acid utilization gene cluster in Aspergillus nidulans.

Authors:  A R Hawkins; A J Francisco Da Silva; C F Roberts
Journal:  Curr Genet       Date:  1985       Impact factor: 3.886

10.  Sequence analysis and transformation by the catabolic 3-dehydroquinase (QUTE) gene from Aspergillus nidulans.

Authors:  A J Da Silva; H Whittington; J Clements; C Roberts; A R Hawkins
Journal:  Biochem J       Date:  1986-12-01       Impact factor: 3.857
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  33 in total

1.  cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme.

Authors:  G McAllister; P Whiting; E A Hammond; M R Knowles; J R Atack; F J Bailey; R Maigetter; C I Ragan
Journal:  Biochem J       Date:  1992-06-15       Impact factor: 3.857

2.  Structure of inositol monophosphatase, the putative target of lithium therapy.

Authors:  R Bone; J P Springer; J R Atack
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-01       Impact factor: 11.205

3.  Differential flux through the quinate and shikimate pathways. Implications for the channelling hypothesis.

Authors:  H K Lamb; J P van den Hombergh; G H Newton; J D Moore; C F Roberts; A R Hawkins
Journal:  Biochem J       Date:  1992-05-15       Impact factor: 3.857

4.  The transcription repressor NmrA is subject to proteolysis by three Aspergillus nidulans proteases.

Authors:  Xiao Zhao; Samantha L Hume; Christopher Johnson; Paul Thompson; Junyong Huang; Joe Gray; Heather K Lamb; Alastair R Hawkins
Journal:  Protein Sci       Date:  2010-07       Impact factor: 6.725

5.  A comparison of the enzymological and biophysical properties of two distinct classes of dehydroquinase enzymes.

Authors:  C Kleanthous; R Deka; K Davis; S M Kelly; A Cooper; S E Harding; N C Price; A R Hawkins; J R Coggins
Journal:  Biochem J       Date:  1992-03-15       Impact factor: 3.857

6.  In vivo overproduction of the pentafunctional arom polypeptide in Aspergillus nidulans affects metabolic flux in the quinate pathway.

Authors:  H K Lamb; C R Bagshaw; A R Hawkins
Journal:  Mol Gen Genet       Date:  1991-06

7.  The purification and characterization of 3-dehydroquinase from Streptomyces coelicolor.

Authors:  P J White; J Young; I S Hunter; H G Nimmo; J R Coggins
Journal:  Biochem J       Date:  1990-02-01       Impact factor: 3.857

8.  crnA encodes a nitrate transporter in Aspergillus nidulans.

Authors:  S E Unkles; K L Hawker; C Grieve; E I Campbell; P Montague; J R Kinghorn
Journal:  Proc Natl Acad Sci U S A       Date:  1991-01-01       Impact factor: 11.205

9.  Efficient independent activity of a monomeric, monofunctional dehydroquinate synthase derived from the N-terminus of the pentafunctional AROM protein of Aspergillus nidulans.

Authors:  J D Moore; J R Coggins; R Virden; A R Hawkins
Journal:  Biochem J       Date:  1994-07-01       Impact factor: 3.857

10.  C-terminal tripeptide Ser-Asn-Leu (SNL) of human D-aspartate oxidase is a functional peroxisome-targeting signal.

Authors:  L Amery; C Brees; M Baes; C Setoyama; R Miura; G P Mannaerts; P P Van Veldhoven
Journal:  Biochem J       Date:  1998-12-01       Impact factor: 3.857
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