Literature DB >> 2829849

The dephosphorylation of inositol 1,4-bisphosphate to inositol in liver and brain involves two distinct Li+-sensitive enzymes and proceeds via inositol 4-phosphate.

C I Ragan1, K J Watling, N S Gee, S Aspley, R G Jackson, G G Reid, R Baker, D C Billington, R J Barnaby, P D Leeson.   

Abstract

1. Hydrolysis of both enantiomers of inositol 1-phosphate and both enantiomers of inositol 4-phosphate to inositol is inhibited by LiCl in liver and brain. 2. The phosphatase activity is predominantly soluble. 3. Inositol 1,4-bisphosphate is also hydrolysed by the soluble fraction of liver and brain. 4. Bisphosphatase activity is inhibited by LiCl, but is less sensitive than monophosphatase activity. 5. The product of bisphosphatase in liver and brain is inositol 4-phosphate.

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Year:  1988        PMID： 2829849      PMCID： PMC1148677          DOI： 10.1042/bj2490143

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  27 in total

Review 1.  Inositol trisphosphate and diacylglycerol as second messengers.

Authors:  M J Berridge
Journal:  Biochem J       Date:  1984-06-01       Impact factor: 3.857

2.  Evidence that inositol 1-phosphate in brain of lithium-treated rats results mainly from phosphatidylinositol metabolism.

Authors:  K E Ackermann; B G Gish; M P Honchar; W R Sherman
Journal:  Biochem J       Date:  1987-03-01       Impact factor: 3.857

3.  A new micromethod for the colorimetric determination of inorganic phosphate.

Authors:  K Itaya; M Ui
Journal:  Clin Chim Acta       Date:  1966-09       Impact factor: 3.786

4.  Phosphoinositide interconversion in thrombin-stimulated human platelets.

Authors:  D B Wilson; E J Neufeld; P W Majerus
Journal:  J Biol Chem       Date:  1985-01-25       Impact factor: 5.157

5.  Analysis of the metabolic turnover of the individual phosphate groups of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. Validation of novel analytical techniques by using 32P-labelled lipids from erythrocytes.

Authors:  P T Hawkins; R H Michell; C J Kirk
Journal:  Biochem J       Date:  1984-03-15       Impact factor: 3.857

6.  The second messenger linking receptor activation to internal Ca release in liver.

Authors:  G M Burgess; P P Godfrey; J S McKinney; M J Berridge; R F Irvine; J W Putney
Journal:  Nature       Date:  1984 May 3-9       Impact factor: 49.962

7.  The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane.

Authors:  C P Downes; M C Mussat; R H Michell
Journal:  Biochem J       Date:  1982-04-01       Impact factor: 3.857

8.  Stepwise enzymatic dephosphorylation of inositol 1,4,5-trisphosphate to inositol in liver.

Authors:  D J Storey; S B Shears; C J Kirk; R H Michell
Journal:  Nature       Date:  1984 Nov 22-28       Impact factor: 49.962

9.  The polyphosphoinositide phosphodiesterase of erythrocyte membranes.

Authors:  C P Downes; R H Michell
Journal:  Biochem J       Date:  1981-07-15       Impact factor: 3.857

10.  Evidence that lithium alters phosphoinositide metabolism: chronic administration elevates primarily D-myo-inositol-1-phosphate in cerebral cortex of the rat.

Authors:  W R Sherman; A L Leavitt; M P Honchar; L M Hallcher; B E Phillips
Journal:  J Neurochem       Date:  1981-06       Impact factor: 5.372
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  28 in total

Review 1.  Novel insights into lithium's mechanism of action: neurotrophic and neuroprotective effects.

Authors:  Jorge A Quiroz; Rodrigo Machado-Vieira; Carlos A Zarate; Husseini K Manji
Journal:  Neuropsychobiology       Date:  2010-05-07       Impact factor: 2.328

2.  cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme.

Authors:  G McAllister; P Whiting; E A Hammond; M R Knowles; J R Atack; F J Bailey; R Maigetter; C I Ragan
Journal:  Biochem J       Date:  1992-06-15       Impact factor: 3.857

3.  Bovine inositol monophosphatase. Modification, identification and mutagenesis of reactive cysteine residues.

Authors:  M R Knowles; N Gee; G McAllister; C I Ragan; P J Greasley; M G Gore
Journal:  Biochem J       Date:  1992-07-15       Impact factor: 3.857

Review 4.  Metabolism of the inositol phosphates produced upon receptor activation.

Authors:  S B Shears
Journal:  Biochem J       Date:  1989-06-01       Impact factor: 3.857

5.  Modification of myo-inositol monophosphatase by the arginine-specific reagent phenylglyoxal.

Authors:  R G Jackson; N S Gee; C I Ragan
Journal:  Biochem J       Date:  1989-12-01       Impact factor: 3.857

6.  A monoclonal antibody to bovine brain inositol monophosphatase. Immunoaffinity purification of the brain and kidney enzymes and evidence for their structural identity.

Authors:  N S Gee; S Howell; G Ryan; C I Ragan
Journal:  Biochem J       Date:  1989-12-15       Impact factor: 3.857

7.  Hydrolysis of inositol phosphates by plant cell extracts.

Authors:  S K Joseph; T Esch; W D Bonner
Journal:  Biochem J       Date:  1989-12-15       Impact factor: 3.857

8.  Inhibition of agonist-stimulated inositol lipid metabolism by the anticonvulsant carbamazepine in rat hippocampus.

Authors:  E E McDermott; S D Logan
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

9.  The phosphoinositide signaling cycle in myelin requires cooperative interaction with the axon.

Authors:  G Chakraborty; A Drivas; R Ledeen
Journal:  Neurochem Res       Date:  1999-02       Impact factor: 3.996

10.  Analysis of [3H]inositol phosphate formation and metabolism in cerebral-cortical slices. Evidence for a dual metabolism of inositol 1,4-bisphosphate.

Authors:  I H Batty; S R Nahorski
Journal:  Biochem J       Date:  1992-12-15       Impact factor: 3.857
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