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Literature DB >> 1311252

Immunoglobulin V gene replacement is caused by the intramolecular DNA deletion mechanism.

S Usuda¹, T Takemori, M Matsuoka, T Shirasawa, K Yoshida, A Mori, K Ishizaka, H Sakano.

Abstract

Circular DNA resulting from V gene replacement was studied with an A-MuLV transformed cell line containing ablts. This cell line undergoes V gene replacement at elevated temperatures in the immunoglobulin (Ig) heavy chain (H) gene. Examination of circular DNA revealed that a heptamer-related sequence (TACTGTG) within the coding region of VDJ was joined to the recombination signal sequence (RSS) of a germline VH segment. This provides direct evidence for a intramolecular DNA deletion mechanism for V gene replacement. In the pre-B cell line as well as in in vivo lymphocytes, unusual circular DNAs were found which were structurally similar to the V gene replacement circles. They represented excision products of the deletion type recombination between one complete RSS and a heptamer-like sequence in the Ig H region.

Entities: Chemical

Mesh：

Substances：

Year: 1992 PMID： 1311252 PMCID： PMC556493 DOI： 10.1002/j.1460-2075.1992.tb05093.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

40 in total

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Journal: Science Date: 1984-11-30 Impact factor: 47.728

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Authors: D D Davis; K Yoshida; L Kingsbury; H Sakano
Journal: J Exp Med Date: 1991-03-01 Impact factor: 14.307

12 in total

1. Assessing the pathogenic potential of the V(D)J recombinase by interlocus immunoglobulin light-chain gene rearrangement.

Authors: S N Bailey; N Rosenberg
Journal: Mol Cell Biol Date: 1997-02 Impact factor: 4.272

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Authors: S M Lewis; E Agard; S Suh; L Czyzyk
Journal: Mol Cell Biol Date: 1997-06 Impact factor: 4.272

Review 3. B cell receptor editing in tolerance and autoimmunity.

Authors: Eline T Luning Prak; Marc Monestier; Robert A Eisenberg
Journal: Ann N Y Acad Sci Date: 2011-01-05 Impact factor: 5.691

4. Two distinct populations of H chain-edited B cells show differential surrogate L chain dependence.

Authors: Pamela B Nakajima; Kerstin Kiefer; Amy Price; Gayle C Bosma; Melvin J Bosma
Journal: J Immunol Date: 2009-03-15 Impact factor: 5.422

5. An activation-induced cytidine deaminase-independent mechanism of secondary VH gene rearrangement in preimmune human B cells.

Authors: Nancy S Longo; Gabrielle J Grundy; Jisoo Lee; Martin Gellert; Peter E Lipsky
Journal: J Immunol Date: 2008-12-01 Impact factor: 5.422

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Authors: T Shimizu; H Yamagishi
Journal: EMBO J Date: 1992-12 Impact factor: 11.598

7. Immunoglobulin heavy chain variable region gene replacement As a mechanism for receptor revision in rheumatoid arthritis synovial tissue B lymphocytes.

Authors: K Itoh; E Meffre; E Albesiano; A Farber; D Dines; P Stein; S E Asnis; R A Furie; R I Jain; N Chiorazzi
Journal: J Exp Med Date: 2000-10-16 Impact factor: 14.307

8. Phylogenetic conservation of the 3' cryptic recombination signal sequence (3'cRSS) in the VH genes of jawed vertebrates.

Authors: Yi Sun; Zhancai Liu; Zhaoyong Li; Zhengxing Lian; Yaofeng Zhao
Journal: Front Immunol Date: 2012-12-20 Impact factor: 7.561

9. Heavy chain variable (VH) region diversity generated by VH gene replacement in the progeny of a single precursor cell transformed with a temperature-sensitive mutant of Abelson murine leukemia virus.

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Journal: J Exp Med Date: 1992-10-01 Impact factor: 14.307

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Authors: Marco Davila; Feifei Liu; Lindsay G Cowell; Anne E Lieberman; Emily Heikamp; Anjali Patel; Garnett Kelsoe
Journal: J Exp Med Date: 2007-12-03 Impact factor: 14.307