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Literature DB >> 1900083

Circular DNA resulting from recombination between V-(D)-J joining signals and switch repetitive sequences in mouse thymocytes.

D D Davis¹, K Yoshida, L Kingsbury, H Sakano.

Abstract

During the course of analyzing circular DNA in mouse thymocytes, novel recombinants were identified with immunoglobulin heavy chain joining gene and switch region probes. These circles represent excision products of recombination between the heptamer-nonamer motif for V-(D)-J joining and a repetitive sequence for class switching. The molecular mechanisms that generate "hybrid circles" are discussed.

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Year: 1991 PMID： 1900083 PMCID： PMC2118817 DOI： 10.1084/jem.173.3.743

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

16 in total

1. Circular DNA is a product of the immunoglobulin class switch rearrangement.

Authors: U von Schwedler; H M Jäck; M Wabl
Journal: Nature Date: 1990-05-31 Impact factor: 49.962

2. Isolation of an excision product of T-cell receptor alpha-chain gene rearrangements.

Authors: S Fujimoto; H Yamagishi
Journal: Nature Date: 1987 May 21-27 Impact factor: 49.962

3. Circular DNA is excised by immunoglobulin class switch recombination.

Authors: T Iwasato; A Shimizu; T Honjo; H Yamagishi
Journal: Cell Date: 1990-07-13 Impact factor: 41.582

Review 4. The role of chromosomal translocations in B- and T-cell neoplasia.

Authors: L C Showe; C M Croce
Journal: Annu Rev Immunol Date: 1987 Impact factor: 28.527

5. Two pairs of recombination signals are sufficient to cause immunoglobulin V-(D)-J joining.

Authors: S Akira; K Okazaki; H Sakano
Journal: Science Date: 1987-11-20 Impact factor: 47.728

6. Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

Authors: F W Alt; D Baltimore
Journal: Proc Natl Acad Sci U S A Date: 1982-07 Impact factor: 11.205

Review 7. Somatic generation of antibody diversity.

Authors: S Tonegawa
Journal: Nature Date: 1983-04-14 Impact factor: 49.962

8. Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes.

Authors: Y Kurosawa; H von Boehmer; W Haas; H Sakano; A Trauneker; S Tonegawa
Journal: Nature Date: 1981-04-16 Impact factor: 49.962

9. Immunoglobulin switch circular DNA in the mouse infected with Nippostrongylus brasiliensis: evidence for successive class switching from mu to epsilon via gamma 1.

Authors: K Yoshida; M Matsuoka; S Usuda; A Mori; K Ishizaka; H Sakano
Journal: Proc Natl Acad Sci U S A Date: 1990-10 Impact factor: 11.205

Circular DNA resulting from recombination between V-(D)-J joining signals and switch repetitive sequences in mouse thymocytes.

1. Circular DNA is a product of the immunoglobulin class switch rearrangement.

2. Isolation of an excision product of T-cell receptor alpha-chain gene rearrangements.

3. Circular DNA is excised by immunoglobulin class switch recombination.

Review 4. The role of chromosomal translocations in B- and T-cell neoplasia.

5. Two pairs of recombination signals are sufficient to cause immunoglobulin V-(D)-J joining.

6. Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

Review 7. Somatic generation of antibody diversity.

8. Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes.

9. Immunoglobulin switch circular DNA in the mouse infected with Nippostrongylus brasiliensis: evidence for successive class switching from mu to epsilon via gamma 1.

10. DNA sequencing with chain-terminating inhibitors.

Review 1. DNA sequences at immunoglobulin switch region recombination sites.

2. Characterization of a lymphoblastoid line deleted for lambda immunglobulin genes.

3. Immunoglobulin V gene replacement is caused by the intramolecular DNA deletion mechanism.

Review 4. DNA-Topology Simplification by Topoisomerases.