Literature DB >> 12925990

Chemical and functional diversity of small molecule ligands for RNA.

Thomas Hermann1.   

Abstract

Functional RNAs such as ribosomal RNA and structured domains of mRNA are targets for small molecule ligands that can act as modulators of the RNA biological activity. Natural ligands for RNA display a bewildering structural and chemical complexity that has yet to be matched by synthetic RNA binders. Comparison of natural and artificial ligands for RNA may help to direct future approaches to design and synthesize potent novel scaffolds for specific recognition of RNA targets. Copyright 2003 Wiley Periodicals, Inc.

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Year:  2003        PMID： 12925990     DOI： 10.1002/bip.10410

Source DB:  PubMed          Journal:  Biopolymers        ISSN： 0006-3525            Impact factor:   2.505


  21 in total

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4.  Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-Targeted Bioactive Ligands.

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5.  1,3-Diazepanes of natural product-like complexity from cyanamide-induced rearrangement of epoxy-delta-lactams.

Authors:  Sanjay Dutta; Cody J Higginson; Bao T Ho; Kevin D Rynearson; Sergey M Dibrov; Thomas Hermann
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6.  A modular approach to synthetic RNA binders of the hepatitis C virus internal ribosome entry site.

Authors:  Maia Carnevali; Jerod Parsons; David L Wyles; Thomas Hermann
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Review 7.  The structural and functional diversity of metabolite-binding riboswitches.

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9.  Multivalent binding oligomers inhibit HIV Tat-TAR interaction critical for viral replication.

Authors:  Deyun Wang; Jaclyn Iera; Heather Baker; Priscilla Hogan; Roger Ptak; Lu Yang; Tracy Hartman; Robert W Buckheit; Alexandre Desjardins; Ao Yang; Pascale Legault; Venkat Yedavalli; Kuan-Teh Jeang; Daniel H Appella
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10.  Noncovalent probes for the investigation of structure and dynamics of protein-nucleic acid assemblies: the case of NC-mediated dimerization of genomic RNA in HIV-1.

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Journal:  Biopolymers       Date:  2009-04       Impact factor: 2.505
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