Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A modular approach to synthetic RNA binders of the hepatitis C virus internal ribosome entry site.

Literature DB >> 20564282

A modular approach to synthetic RNA binders of the hepatitis C virus internal ribosome entry site.

Maia Carnevali¹, Jerod Parsons, David L Wyles, Thomas Hermann.

Abstract

Entities: CellLine Chemical Disease Species

Mesh：

Substances：
Piperidines
RNA, Viral

Year: 2010 PMID： 20564282 PMCID： PMC3517111 DOI： 10.1002/cbic.201000177

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

× No keyword cloud information.

17 in total

Review 1. Chemical and functional diversity of small molecule ligands for RNA.

Authors: Thomas Hermann
Journal: Biopolymers Date: 2003-09 Impact factor: 2.505

Review 2. 2-Deoxystreptamine: central scaffold of aminoglycoside antibiotics.

Authors: Guuske F Busscher; Floris P J T Rutjes; Floris L van Delft
Journal: Chem Rev Date: 2005-03 Impact factor: 60.622

3. Functional architecture of HCV IRES domain II stabilized by divalent metal ions in the crystal and in solution.

Authors: Sergey M Dibrov; Hillary Johnston-Cox; Yi-Hsin Weng; Thomas Hermann
Journal: Angew Chem Int Ed Engl Date: 2007 Impact factor: 15.336

4. Structure-guided discovery of novel aminoglycoside mimetics as antibacterial translation inhibitors.

Authors: Yuefen Zhou; Vlad E Gregor; Zhongxiang Sun; Benjamin K Ayida; Geoffrey C Winters; Douglas Murphy; Klaus B Simonsen; Dionisios Vourloumis; Sarah Fish; Jamie M Froelich; Daniel Wall; Thomas Hermann
Journal: Antimicrob Agents Chemother Date: 2005-12 Impact factor: 5.191

5. Aminoglycoside binding to the hammerhead ribozyme: a general model for the interaction of cationic antibiotics with RNA.

Authors: T Hermann; E Westhof
Journal: J Mol Biol Date: 1998-03-13 Impact factor: 5.469

6. Structure of the hepatitis C virus IRES bound to the human 80S ribosome: remodeling of the HCV IRES.

Authors: Daniel Boehringer; Rolf Thermann; Antje Ostareck-Lederer; Joe D Lewis; Holger Stark
Journal: Structure Date: 2005-11 Impact factor: 5.006

7. Synergy of small molecular inhibitors of hepatitis C virus replication directed at multiple viral targets.

Authors: David L Wyles; Kelly A Kaihara; Florin Vaida; Robert T Schooley
Journal: J Virol Date: 2006-12-20 Impact factor: 5.103

8. Synthesis and SAR of 3,5-diamino-piperidine derivatives: novel antibacterial translation inhibitors as aminoglycoside mimetics.

Authors: Yuefen Zhou; Vlad E Gregor; Benjamin K Ayida; Geoffrey C Winters; Zhongxiang Sun; Douglas Murphy; Greg Haley; Dwight Bailey; Jamie M Froelich; Sarah Fish; Stephen E Webber; Thomas Hermann; Daniel Wall
Journal: Bioorg Med Chem Lett Date: 2006-12-12 Impact factor: 2.823

Review 9. Structure and function of HCV IRES domains.

Authors: Peter J Lukavsky
Journal: Virus Res Date: 2008-07-31 Impact factor: 3.303

10. Conformational inhibition of the hepatitis C virus internal ribosome entry site RNA.

Authors: Jerod Parsons; M Paola Castaldi; Sanjay Dutta; Sergey M Dibrov; David L Wyles; Thomas Hermann
Journal: Nat Chem Biol Date: 2009-09-20 Impact factor: 15.040

14 in total

1. Functional conservation despite structural divergence in ligand-responsive RNA switches.

Authors: Mark A Boerneke; Sergey M Dibrov; Jing Gu; David L Wyles; Thomas Hermann
Journal: Proc Natl Acad Sci U S A Date: 2014-10-27 Impact factor: 11.205

2. Structure of a hepatitis C virus RNA domain in complex with a translation inhibitor reveals a binding mode reminiscent of riboswitches.

Authors: Sergey M Dibrov; Kejia Ding; Nicholas D Brunn; Matthew A Parker; B Mikael Bergdahl; David L Wyles; Thomas Hermann
Journal: Proc Natl Acad Sci U S A Date: 2012-03-19 Impact factor: 11.205

A modular approach to synthetic RNA binders of the hepatitis C virus internal ribosome entry site.

Review 1. Chemical and functional diversity of small molecule ligands for RNA.

Review 2. 2-Deoxystreptamine: central scaffold of aminoglycoside antibiotics.

3. Functional architecture of HCV IRES domain II stabilized by divalent metal ions in the crystal and in solution.

4. Structure-guided discovery of novel aminoglycoside mimetics as antibacterial translation inhibitors.

5. Aminoglycoside binding to the hammerhead ribozyme: a general model for the interaction of cationic antibiotics with RNA.

6. Structure of the hepatitis C virus IRES bound to the human 80S ribosome: remodeling of the HCV IRES.

7. Synergy of small molecular inhibitors of hepatitis C virus replication directed at multiple viral targets.

8. Synthesis and SAR of 3,5-diamino-piperidine derivatives: novel antibacterial translation inhibitors as aminoglycoside mimetics.

Review 9. Structure and function of HCV IRES domains.

10. Conformational inhibition of the hepatitis C virus internal ribosome entry site RNA.

1. Functional conservation despite structural divergence in ligand-responsive RNA switches.

2. Structure of a hepatitis C virus RNA domain in complex with a translation inhibitor reveals a binding mode reminiscent of riboswitches.

Review 3. Synthetic small-molecule RNA ligands: future prospects as therapeutic agents.

Review 4. Theory and Modeling of RNA Structure and Interactions with Metal Ions and Small Molecules.

5. Ligand-responsive RNA mechanical switches.

6. Screening for inhibitors of the hepatitis C virus internal ribosome entry site RNA.

7. RNA Drugs and RNA Targets for Small Molecules: Principles, Progress, and Challenges.

8. Direct observation of aminoglycoside-RNA binding by localized surface plasmon resonance spectroscopy.

Review 9. Hepatitis C virus translation inhibitors targeting the internal ribosomal entry site.

Review 10. The Emerging Role of RNA as a Therapeutic Target for Small Molecules.