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Literature DB >> 12761119

Helicobacter pylori infection induces interleukin-8 receptor expression in the human gastric epithelium.

Fredrik Bäckhed¹, Elisabeth Torstensson, Delphine Seguin, Agneta Richter-Dahlfors, Bachra Rokbi.

Abstract

The gastric pathogen Helicobacter pylori is known to activate multiple proinflammatory signaling pathways in epithelial cells. In this study, we addressed the question of whether expression of the interleukin-8 receptors IL-8RA (CXCR1) and IL-8RB (CXCR2) is upregulated in H. pylori-infected human gastric biopsy samples. Biopsy samples from patients infected with H. pylori strains harboring the cag pathogenicity island (PAI) expressed larger amounts of both receptors. In addition, IL-8RB expression was induced in the gastric epithelial cell line AGS upon infection with a clinical isolate containing the cag PAI, while a strain lacking the cag PAI did not. Our finding suggests that gastric epithelial cells express IL-8R in response to H. pylori infection.

Entities: Disease Species

Mesh：

Substances：

Year: 2003 PMID： 12761119 PMCID： PMC155779 DOI： 10.1128/IAI.71.6.3357-3360.2003

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

15 in total

1. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion.

Authors: S Odenbreit; J Püls; B Sedlmaier; E Gerland; W Fischer; R Haas
Journal: Science Date: 2000-02-25 Impact factor: 47.728

2. Assessment of Helicobacter pylori gene expression within mouse and human gastric mucosae by real-time reverse transcriptase PCR.

Authors: B Rokbi; D Seguin; B Guy; V Mazarin; E Vidor; F Mion; M Cadoz; M J Quentin-Millet
Journal: Infect Immun Date: 2001-08 Impact factor: 3.441

3. Role of epithelial interleukin-8 (IL-8) and neutrophil IL-8 receptor A in Escherichia coli-induced transuroepithelial neutrophil migration.

Authors: G Godaly; A E Proudfoot; R E Offord; C Svanborg; W W Agace
Journal: Infect Immun Date: 1997-08 Impact factor: 3.441

4. Induction of innate immune responses by Escherichia coli and purified lipopolysaccharide correlate with organ- and cell-specific expression of Toll-like receptors within the human urinary tract.

Authors: F Bäckhed; M Söderhäll; P Ekman; S Normark; A Richter-Dahlfors
Journal: Cell Microbiol Date: 2001-03 Impact factor: 3.715

9. The effect of Helicobacter pylori infection and different H. pylori components on the proliferation and apoptosis of gastric epithelial cells and fibroblasts.

Authors: Weronika Gonciarz; Agnieszka Krupa; Krzysztof Hinc; Michał Obuchowski; Anthony P Moran; Adrian Gajewski; Magdalena Chmiela
Journal: PLoS One Date: 2019-08-07 Impact factor: 3.240

9 in total

Helicobacter pylori infection induces interleukin-8 receptor expression in the human gastric epithelium.

1. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion.

2. Assessment of Helicobacter pylori gene expression within mouse and human gastric mucosae by real-time reverse transcriptase PCR.

3. Role of epithelial interleukin-8 (IL-8) and neutrophil IL-8 receptor A in Escherichia coli-induced transuroepithelial neutrophil migration.

4. Induction of innate immune responses by Escherichia coli and purified lipopolysaccharide correlate with organ- and cell-specific expression of Toll-like receptors within the human urinary tract.

5. Transepithelial neutrophil migration is CXCR1 dependent in vitro and is defective in IL-8 receptor knockout mice.

Review 6. Living dangerously: how Helicobacter pylori survives in the human stomach.

7. Gastric mucosal recognition of Helicobacter pylori is independent of Toll-like receptor 4.

8. Comparison of genetic divergence and fitness between two subclones of Helicobacter pylori.

9. Structure and functional expression of a human interleukin-8 receptor.

10. Cloning of complementary DNA encoding a functional human interleukin-8 receptor.

1. Gastrin activates paracrine networks leading to induction of PAI-2 via MAZ and ASC-1.

2. Expression of CXC receptor 1 and 2 in esophageal mucosa of patients with reflux esophagitis.

Review 3. Role of the tumor microenvironment in the pathogenesis of gastric carcinoma.

4. Interleukin 8 and susceptibility to coronary artery disease: a population genetics perspective.

5. Upregulation of C-X-C chemokine receptor type 1 expression is associated with late-stage gastric adenocarcinoma.

6. Helicobacter pylori damages human gallbladder epithelial cells in vitro.

Review 7. CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.

8. Polymorphism in the CagA EPIYA motif impacts development of gastric cancer.

9. The effect of Helicobacter pylori infection and different H. pylori components on the proliferation and apoptosis of gastric epithelial cells and fibroblasts.