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Literature DB >> 19533806

CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.

Abstract

CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, Helicobacter pylori (H pylori). The role of CD74 as a receptor is important because after binding of migration inhibitory factor or H pylori, NF-kappaB and Erk1/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19533806 PMCID： PMC2699002 DOI： 10.3748/wjg.15.2855

Source DB: PubMed Journal: World J Gastroenterol ISSN： 1007-9327 Impact factor: 5.742

70 in total

1. Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells.

Authors: R M Hershberg; D H Cho; A Youakim; M B Bradley; J S Lee; P E Framson; G T Nepom
Journal: J Clin Invest Date: 1998-08-15 Impact factor: 14.808

2. Antisense epidermal growth factor receptor delivered by adenoviral vector blocks tumor growth in human gastric cancer.

Authors: T Hirao; H Sawada; F Koyama; A Watanabe; Y Yamada; T Sakaguchi; M Tatsumi; H Fujimoto; K Emoto; M Narikiyo; N Oridate; H Nakano
Journal: Cancer Gene Ther Date: 1999 Sep-Oct Impact factor: 5.987

3. Invariant chain expression in colon neoplasms.

Authors: Z Jiang; M Xu; L Savas; P LeClair; B F Banner
Journal: Virchows Arch Date: 1999-07 Impact factor: 4.064

4. Class II MHC-expressing myofibroblasts play a role in the immunopathogenesis associated with staphylococcal enterotoxins.

Authors: C A Barrera; I V Pinchuk; J I Saada; G Suarez; D A Bland; E Beswick; P A Adegboyega; R C Mifflin; D W Powell; V E Reyes
Journal: Ann N Y Acad Sci Date: 2004-12 Impact factor: 5.691

5. The Ii41 isoform of invariant chain mediates both positive and negative selection events in T-cell receptor transgenic mice.

Authors: R J Wright; E K Bikoff; B Stockinger
Journal: Immunology Date: 1998-11 Impact factor: 7.397

6. Essential role of MD-2 in TLR4-dependent signaling during Helicobacter pylori-associated gastritis.

Authors: Shunji Ishihara; Mohammad Azharul Karim Rumi; Yasunori Kadowaki; Cesar Francisco Ortega-Cava; Takafumi Yuki; Nagisa Yoshino; Youichi Miyaoka; Hideaki Kazumori; Norihisa Ishimura; Yuji Amano; Yoshikazu Kinoshita
Journal: J Immunol Date: 2004-07-15 Impact factor: 5.422

Review 7. Modification of Helicobacter pylori adhesion to human gastric epithelial cells by antiadhesion agents.

Authors: S Hayashi; T Sugiyama; M Asaka; K Yokota; K Oguma; Y Hirai
Journal: Dig Dis Sci Date: 1998-09 Impact factor: 3.199

8. Macrophage migration inhibitory factor (MIF) regulates host responses to endotoxin through modulation of Toll-like receptor 4 (TLR4).

Authors: Thierry Roger; Céline Froidevaux; Christian Martin; Thierry Calandra
Journal: J Endotoxin Res Date: 2003

9. Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cells.

Authors: Michael F Smith; Anastasia Mitchell; Guolian Li; Song Ding; Ann Marie Fitzmaurice; Kieran Ryan; Sheila Crowe; Joanna B Goldberg
Journal: J Biol Chem Date: 2003-06-13 Impact factor: 5.157

10. MIF signal transduction initiated by binding to CD74.

Authors: Lin Leng; Christine N Metz; Yan Fang; Jing Xu; Seamas Donnelly; John Baugh; Thomas Delohery; Yibang Chen; Robert A Mitchell; Richard Bucala
Journal: J Exp Med Date: 2003-06-02 Impact factor: 14.307

32 in total

1. Migration inhibitory factor enhances inflammation via CD74 in cartilage end plates with Modic type 1 changes on MRI.

Authors: Chengjie Xiong; Bo Huang; Yanping Cun; Bayan G Aghdasi; Yue Zhou
Journal: Clin Orthop Relat Res Date: 2014-02-26 Impact factor: 4.176

2. A novel regulatory pathway for autoimmune disease: binding of partial MHC class II constructs to monocytes reduces CD74 expression and induces both specific and bystander T-cell tolerance.

Authors: Arthur A Vandenbark; Roberto Meza-Romero; Gil Benedek; Shayne Andrew; Jianya Huan; Yuan K Chou; Abigail C Buenafe; Rony Dahan; Yoram Reiter; Jeffery L Mooney; Halina Offner; Gregory G Burrows
Journal: J Autoimmun Date: 2012-09-29 Impact factor: 7.094

3. CD74 and macrophage migration inhibitory factor as therapeutic targets in gastric cancer.

Authors: Ying-Xia Zheng; Ming Yang; Ting-Ting Rong; Xiang-Liang Yuan; Yan-Hui Ma; Zhi-Hao Wang; Li-Song Shen; Long Cui
Journal: World J Gastroenterol Date: 2012-05-14 Impact factor: 5.742

4. Inflammatory Marker Testing Identifies CD74 Expression in Melanoma Tumor Cells, and Its Expression Associates with Favorable Survival for Stage III Melanoma.

Authors: Suhendan Ekmekcioglu; Michael A Davies; Keiji Tanese; Jason Roszik; Myung Shin-Sim; Roland L Bassett; Denái R Milton; Scott E Woodman; Victor G Prieto; Jeffrey E Gershenwald; Donald L Morton; Dave S Hoon; Elizabeth A Grimm
Journal: Clin Cancer Res Date: 2016-01-18 Impact factor: 12.531

10. Modulating mammary tumor growth, metastasis and immunosuppression by siRNA-induced MIF reduction in tumor microenvironment.

Authors: M Zhang; L Yan; J A Kim
Journal: Cancer Gene Ther Date: 2015-09-25 Impact factor: 5.987