Literature DB >> 19158258

Polymorphism in the CagA EPIYA motif impacts development of gastric cancer.

Kathleen R Jones1, Young Min Joo, Sungil Jang, Yun-Jung Yoo, Hak Sung Lee, In-Sik Chung, Cara H Olsen, Jeannette M Whitmire, D Scott Merrell, Jeong-Heon Cha.   

Abstract

Helicobacter pylori causes diseases ranging from gastritis to peptic ulcer disease to gastric cancer. Geographically, areas with high incidences of H. pylori infection often overlap with areas with high incidences of gastric cancer, which remains one of the leading causes of cancer-related deaths worldwide. Strains of H. pylori that carry the virulence factor cytotoxin-associated gene A (cagA) are much more likely to be associated with the development of gastric cancer. Moreover, particular C-terminal polymorphisms in CagA vary by geography and have been suggested to influence disease development. We conducted a large-scale molecular epidemiologic analysis of South Korean strains and herein report a statistical link between the East Asian CagA EPIYA-ABD genotype and the development of gastric cancer. Characterization of a subset of the Korean isolates showed that all strains from cancer patients expressed and delivered phosphorylatable CagA to host cells, whereas the presence of the cagA gene did not strictly correlate to expression and delivery of CagA in all noncancer strains.

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Year:  2009        PMID： 19158258      PMCID： PMC2668329          DOI： 10.1128/JCM.02330-08

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  48 in total

Review 1.  Integrating the MAP kinase signal into the G1 phase cell cycle machinery.

Authors:  K Roovers; R K Assoian
Journal:  Bioessays       Date:  2000-09       Impact factor: 4.345

2.  Stomach cancer incidence in the world.

Authors:  S Yamamoto
Journal:  Jpn J Clin Oncol       Date:  2001-09       Impact factor: 3.019

3.  SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein.

Authors:  Hideaki Higashi; Ryouhei Tsutsumi; Syuichi Muto; Toshiro Sugiyama; Takeshi Azuma; Masahiro Asaka; Masanori Hatakeyama
Journal:  Science       Date:  2001-12-13       Impact factor: 47.728

4.  Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori.

Authors:  E D Segal; J Cha; J Lo; S Falkow; L S Tompkins
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-07       Impact factor: 11.205

Review 5.  Infection with Helicobacter pylori.

Authors: 
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6.  Virulence factors of Helicobacter pylori in Korean isolates do not influence proinflammatory cytokine gene expression and apoptosis in human gastric epithelial cells, nor do these factors influence the clinical outcome.

Authors:  J M Kim; J S Kim; H C Jung; I S Song; C Y Kim
Journal:  J Gastroenterol       Date:  2000-12       Impact factor: 7.527

7.  c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs.

Authors:  Markus Stein; Fabio Bagnoli; Robert Halenbeck; Rino Rappuoli; Wendy J Fantl; Antonello Covacci
Journal:  Mol Microbiol       Date:  2002-02       Impact factor: 3.501

8.  Correlation between variation of the 3' region of the cagA gene in Helicobacter pylori and disease outcome in Japan.

Authors:  Takeshi Azuma; Akiyo Yamakawa; Shiho Yamazaki; Kanako Fukuta; Masahiro Ohtani; Yoshiyuki Ito; Manabu Dojo; Yukinao Yamazaki; Masaru Kuriyama
Journal:  J Infect Dis       Date:  2002-11-11       Impact factor: 5.226

9.  Helicobacter pylori enter and survive within multivesicular vacuoles of epithelial cells.

Authors:  Manuel R Amieva; Nina R Salama; Lucy S Tompkins; Stanley Falkow
Journal:  Cell Microbiol       Date:  2002-10       Impact factor: 3.715

10.  Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites.

Authors:  Hideaki Higashi; Ryouhei Tsutsumi; Akiko Fujita; Shiho Yamazaki; Masahiro Asaka; Takeshi Azuma; Masanori Hatakeyama
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-21       Impact factor: 11.205
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  59 in total

1.  The geographic origin of Helicobacter pylori influences the association of the homB gene with gastric cancer.

Authors:  Jieun Kang; Kathleen R Jones; Sungil Jang; Cara H Olsen; Yun-Jung Yoo; D Scott Merrell; Jeong-Heon Cha
Journal:  J Clin Microbiol       Date:  2012-01-11       Impact factor: 5.948

2.  J-Western forms of Helicobacter pylori cagA constitute a distinct phylogenetic group with a widespread geographic distribution.

Authors:  Stacy S Duncan; Pieter L Valk; Carrie L Shaffer; Seth R Bordenstein; Timothy L Cover
Journal:  J Bacteriol       Date:  2012-01-13       Impact factor: 3.490

3.  Association between Helicobacter pylori virulence factors and gastroduodenal diseases in Okinawa, Japan.

Authors:  Osamu Matsunari; Seiji Shiota; Rumiko Suzuki; Masahide Watada; Nagisa Kinjo; Kazunari Murakami; Toshio Fujioka; Fukunori Kinjo; Yoshio Yamaoka
Journal:  J Clin Microbiol       Date:  2011-12-21       Impact factor: 5.948

4.  Helicobacter pylori outer membrane protein, HomC, shows geographic dependent polymorphism that is influenced by the Bab family.

Authors:  Aeryun Kim; Stephanie L Servetas; Jieun Kang; Jinmoon Kim; Sungil Jang; Yun Hui Choi; Hanfu Su; Yeong-Eui Jeon; Youngmin A Hong; Yun-Jung Yoo; D Scott Merrell; Jeong-Heon Cha
Journal:  J Microbiol       Date:  2016-11-26       Impact factor: 3.422

5.  CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease.

Authors:  Effrosini G Panayotopoulou; Dionyssios N Sgouras; Konstantinos S Papadakos; Kalliopi Petraki; Sébastien Breurec; Spyros Michopoulos; Gerassimos Mantzaris; George Papatheodoridis; Andreas Mentis; Athanasios Archimandritis
Journal:  J Clin Microbiol       Date:  2010-04-14       Impact factor: 5.948

Review 6.  Polymorphism in the Helicobacter pylori CagA and VacA toxins and disease.

Authors:  Dacie R Bridge; D Scott Merrell
Journal:  Gut Microbes       Date:  2013-02-04

7.  Epidemiological link between gastric disease and polymorphisms in VacA and CagA.

Authors:  Sungil Jang; Kathleen R Jones; Cara H Olsen; Young Min Joo; Yun-Jung Yoo; In-Sik Chung; Jeong-Heon Cha; D Scott Merrell
Journal:  J Clin Microbiol       Date:  2009-12-02       Impact factor: 5.948

8.  CagA EPIYA polymorphisms in Colombian Helicobacter pylori strains and their influence on disease-associated cellular responses.

Authors:  Carlos Alberto Fajardo; Andrés Javier Quiroga; Andrea Coronado; Karen Labrador; Nicole Acosta; Pilar Delgado; Carlos Jaramillo; María Mercedes Bravo
Journal:  World J Gastrointest Oncol       Date:  2013-03-15

9.  CagL polymorphisms between East Asian and Western Helicobacter pylori are associated with different abilities to induce IL-8 secretion.

Authors:  Yun Hui Choi; Jing Lai; Myeong-A Kim; Aeryun Kim; Jinmoon Kim; Hanfu Su; Linhu Ge; Jeong-Heon Cha
Journal:  J Microbiol       Date:  2021-06-01       Impact factor: 3.422

10.  Predominant mucosal IL-8 mRNA expression in non-cagA Thais is risk for gastric cancer.

Authors:  Sirikan Yamada; Shunji Kato; Takeshi Matsuhisa; Luksana Makonkawkeyoon; Masaru Yoshida; Thiraphat Chakrabandhu; Nirush Lertprasertsuk; Pawit Suttharat; Bandhuphat Chakrabandhu; Shin Nishiumi; Wilaiwan Chongraksut; Takeshi Azuma
Journal:  World J Gastroenterol       Date:  2013-05-21       Impact factor: 5.742
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