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Literature DB >> 1270073

Distribution of spontaneous chromosome breaks in human chromosomes.

Abstract

Localization of chromosome breaks in human chromosomes was analyzed in 264 peripheral lymphocyte cultures. Three hundred and sixty-nine chromosome breaks could be exactly localized to a chromosome band or region of the Paris Conference nomenclature. The distribution of breaks in the chromosome regions was found to be nonrandom. Chromosome 3 alone had 23% of the breaks and region 3p2 had 13% of the total breaks. Some other chromosome regions, such as 5p1, 9q1, 14q2, and 16q2 also displayed clustering of breaks. Sex chromosomes had less breaks than expected. Spontaneous chromosome breaks were almost exclusively located in the lightly stained G bands.

Entities: Species

Mesh：

Year: 1976 PMID： 1270073 DOI： 10.1007/BF00291497

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

16 in total

Distribution of spontaneous chromosome breaks in human chromosomes.

1. Nonrandom distribution of chromosome breaks in Fanconi's anemia.

2. New technique for distinguishing between human chromosomes.

3. Structural variation in human nitotic chromosomes.

4. High resolution studies on the pattern of induced exchanges in the human karyotype.

5. Preferential location of x-ray induced chromosome breakage in the R-bands of human chromosomes.

6. Radiation-induced non-random chromosome breakage.

7. The lymphocyte as a dosimeter: comparison of somatic chromosome aberrations in 522 newborn infants and 602 mothers.

8. Chromosomal alterations in three age groups of human females.

9. The differential distribution of X-ray induced chromosome lesions in trypsin-banded preparations from human subjects.

10. Apparently spontaneous chromosome damage in human leukocytes and the nature of chromatid gaps.

1. The frequency and distribution of sister chromatid exchanges in human chromosomes.

2. No increased chromosome breakage in three Bloom's syndrome heterozygotes.

3. The constitutional fragility of chromosome 12 in a case of 46,XX,var(12)(gh',RHG,CAG,CBG).

4. Population cytogenetics of folate-sensitive fragile sites. I. Common fragile sites.

5. Translocations of chromosome 12. II. A comparison of the distribution of sites of spontaneous and induced breakages.

6. Unstable familial translocations: A t(11;22)mat inherited as a t(11;15).

7. Partial deletion of the short arm of chromosome 3.

8. Hotspots of mutation and breakage in dog and human chromosomes.

9. DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes.

10. Temporary increase in chromosome breakage in an infant prenatally exposed to lead.