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Literature DB >> 50279

The differential distribution of X-ray induced chromosome lesions in trypsin-banded preparations from human subjects.

Abstract

The distribution of X-ray induced aberrations between trypsin-banded regions within human chromosomes has been studied in over a thousand cells from normal and abnormal individuals. An analysis of this data has been performed for each type of aberration separately, taking into account the relative amount of material at risk in reach region. A number of significant deviations from expectation were detected but many of these could be explained in terms of the failure of detection of some aberrations.

Entities: Species

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Substances：
Trypsin

Year: 1975 PMID： 50279 DOI： 10.1007/bf00278548

Source DB: PubMed Journal: Humangenetik ISSN： 0018-7348

9 in total

5 in total

The differential distribution of X-ray induced chromosome lesions in trypsin-banded preparations from human subjects.

1. An analysis of the break points of structural rearrangements in man.

2. A rapid banding technique for human chromosomes.

3. Incidence and mutation rates of structural rearrangements of the autosomes in man.

4. The sites of radiation induced-breakage in human lymphocyte chromosomes, determined by quinacrine fluorescence.

5. High resolution studies on the pattern of induced exchanges in the human karyotype.

6. Preferential location of x-ray induced chromosome breakage in the R-bands of human chromosomes.

7. Radiation-induced non-random chromosome breakage.

8. Distortion hypothesis: an alternative to a limited number of sites for radiation-induced chromosome exchange.

9. Randomness in the formation of radiation-indued chromosome aberrations.

1. Distribution of spontaneous chromosome breaks in human chromosomes.

2. Application of chromosome banding techniques to the study of primary chromosome structural changes.

3. The pattern of radiation-induced transmissible aberrations in a human cell culture.

4. Structural variability of human chromosome 9 in relation to its evolution.

5. Distribution of radiation induced lesions in human chromosomes and dose-effect relation analysed with G-banding.