Literature DB >> 469900

No increased chromosome breakage in three Bloom's syndrome heterozygotes.

E M Kuhn, E Therman.   

Abstract

The frequency of chromosome aberrations in the lymphocytes of three established heterozygotes for the Bloom's syndrome gene (ages 67, 57, 46) was compared to that in controls (ages 68, 67, 61, 46, 34). The main part of the study was done on coded slides. No difference was found between the heterozygotes and the control group, except for one control (aged 46) who had a significantly higher number of chromosome aberrations than the others.

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Year:  1979        PMID： 469900      PMCID： PMC1012695          DOI： 10.1136/jmg.16.3.219

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  17 in total

1.  CHROMOSOMAL BREAKAGE IN A RARE AND PROBABLY GENETICALLY DETERMINED SYNDROME OF MAN.

Authors:  J GERMAN; R ARCHIBALD; D BLOOM
Journal:  Science       Date:  1965-04-23       Impact factor: 47.728

2.  Bloom's syndrome in two Dutch families.

Authors:  T W Hustinx; B G Ter Haar; J M Scheres; F J Rutten; C M Weemaes; R L Hoppe; A H Janssen
Journal:  Clin Genet       Date:  1977-08       Impact factor: 4.438

Review 3.  Genes which increase chromosomal instability in somatic cells and predispose to cancer.

Authors:  J German
Journal:  Prog Med Genet       Date:  1972

4.  Fanconi's anaemia in the genetics of neoplasia.

Authors:  M Swift
Journal:  Nature       Date:  1971-04-09       Impact factor: 49.962

5.  A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes.

Authors:  R S Chaganti; S Schonberg; J German
Journal:  Proc Natl Acad Sci U S A       Date:  1974-11       Impact factor: 11.205

6.  Cytological demonstration of mitotic crossing-over in man.

Authors:  E Therman; E M Kuhn
Journal:  Cytogenet Cell Genet       Date:  1976

7.  Localization by Q-banding of mitotic chiasmata in cases of Bloom's syndrome.

Authors:  E M Kuhn
Journal:  Chromosoma       Date:  1976-08-04       Impact factor: 4.316

8.  Chromatid exchanges in ataxia telangiectasia, Bloom syndrome, Werner syndrome, and xeroderma pigmentosum.

Authors:  C R Bartram; T Koske-Westphal; E Passarge
Journal:  Ann Hum Genet       Date:  1976-07       Impact factor: 1.670

9.  Mitotic chiasmata and other quadriradials in mitomycin C-treated Bloom's syndrome lymphocytes.

Authors:  E M Kuhn
Journal:  Chromosoma       Date:  1978-04-25       Impact factor: 4.316

10.  Cytogenetic studies in control men and women. I. Variations in aberration frequencies in 29,709 metaphases from 305 cultures obtained over a three-year period.

Authors:  L G Littlefield; K O Goh
Journal:  Cytogenet Cell Genet       Date:  1973
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  4 in total

1.  In vivo chromosomal instability in ataxia-telangiectasia homozygotes and heterozygotes.

Authors:  M P Rosin; H D Ochs
Journal:  Hum Genet       Date:  1986-12       Impact factor: 4.132

2.  Evidence for increased in vivo mutation and somatic recombination in Bloom's syndrome.

Authors:  R G Langlois; W L Bigbee; R H Jensen; J German
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

Review 3.  Mitotic crossing-over and segregation in man.

Authors:  E Therman; E M Kuhn
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

4.  Evidence for chromosome instability in vivo in Bloom syndrome: increased numbers of micronuclei in exfoliated cells.

Authors:  M P Rosin; J German
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132
  4 in total

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