OBJECTIVE: To estimate the average scatterer properties from ultrasonic backscatter in tissues for evaluating differences between neoplastic and healthy tissues. METHODS: Parametric images of 8 retired breeder rats in which spontaneous mammary tumors had developed were created by superimposing color-coded pixels related to the estimated average scatterer properties on conventional gray scale B-mode images. RESULTS: The images showed a distinct difference between the tumors and surrounding healthy tissues. Analysis of the average scatterer diameters and acoustic concentrations showed a statistically significant difference (P < .05) between estimates inside and outside the tumors for most of the cases. Scatterer sizes inside the tumors were on average 30% larger than scatterer sizes in surrounding normal tissues. A feature analysis plot showed that there was a distinct difference between results obtained inside and outside the tumors. CONCLUSIONS: Parametric imaging that uses estimates of scatterer properties in tissues may lead to detection and characterization (diagnosis) of diseased tissues on conventional sonographic scanning systems.
OBJECTIVE: To estimate the average scatterer properties from ultrasonic backscatter in tissues for evaluating differences between neoplastic and healthy tissues. METHODS: Parametric images of 8 retired breeder rats in which spontaneous mammary tumors had developed were created by superimposing color-coded pixels related to the estimated average scatterer properties on conventional gray scale B-mode images. RESULTS: The images showed a distinct difference between the tumors and surrounding healthy tissues. Analysis of the average scatterer diameters and acoustic concentrations showed a statistically significant difference (P < .05) between estimates inside and outside the tumors for most of the cases. Scatterer sizes inside the tumors were on average 30% larger than scatterer sizes in surrounding normal tissues. A feature analysis plot showed that there was a distinct difference between results obtained inside and outside the tumors. CONCLUSIONS: Parametric imaging that uses estimates of scatterer properties in tissues may lead to detection and characterization (diagnosis) of diseased tissues on conventional sonographic scanning systems.
Authors: Goutam Ghoshal; Jeremy P Kemmerer; Chandra Karunakaran; Rita J Miller; Michael L Oelze Journal: IEEE Trans Ultrason Ferroelectr Freq Control Date: 2016-01-14 Impact factor: 2.725
Authors: Barbara L McFarlin; William D O'Brien; Michael L Oelze; James F Zachary; Rosemary C White-Traut Journal: J Ultrasound Med Date: 2006-08 Impact factor: 2.153
Authors: B L McFarlin; T A Bigelow; Y Laybed; W D O'Brien; M L Oelze; J S Abramowicz Journal: Ultrasound Obstet Gynecol Date: 2010-08 Impact factor: 7.299