| Literature DB >> 12271122 |
Ian T Paulsen1, Rekha Seshadri, Karen E Nelson, Jonathan A Eisen, John F Heidelberg, Timothy D Read, Robert J Dodson, Lowell Umayam, Lauren M Brinkac, Maureen J Beanan, Sean C Daugherty, Robert T Deboy, A Scott Durkin, James F Kolonay, Ramana Madupu, William C Nelson, Bola Ayodeji, Margaret Kraul, Jyoti Shetty, Joel Malek, Susan E Van Aken, Steven Riedmuller, Herve Tettelin, Steven R Gill, Owen White, Steven L Salzberg, David L Hoover, Luther E Lindler, Shirley M Halling, Stephen M Boyle, Claire M Fraser.
Abstract
The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent, Brucella suis, was determined. Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence. Analysis of the B. suis genome reveals transport and metabolic capabilities akin to soil/plant-associated bacteria. Extensive gene synteny between B. suis chromosome 1 and the genome of the plant symbiont Mesorhizobium loti emphasizes the similarity between this animal pathogen and plant pathogens and symbionts. A limited repertoire of genes homologous to known bacterial virulence factors were identified.Entities:
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Year: 2002 PMID： 12271122 PMCID： PMC130601 DOI： 10.1073/pnas.192319099
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205