| Literature DB >> 11756688 |
Vito G DelVecchio1, Vinayak Kapatral, Rajendra J Redkar, Guy Patra, Cesar Mujer, Tamara Los, Natalia Ivanova, Iain Anderson, Anamitra Bhattacharyya, Athanasios Lykidis, Gary Reznik, Lynn Jablonski, Niels Larsen, Mark D'Souza, Axel Bernal, Mikhail Mazur, Eugene Goltsman, Eugene Selkov, Philip H Elzer, Sue Hagius, David O'Callaghan, Jean-Jacques Letesson, Robert Haselkorn, Nikos Kyrpides, Ross Overbeek.
Abstract
Brucella melitensis is a facultative intracellular bacterial pathogen that causes abortion in goats and sheep and Malta fever in humans. The genome of B. melitensis strain 16M was sequenced and found to contain 3,294,935 bp distributed over two circular chromosomes of 2,117,144 bp and 1,177,787 bp encoding 3,197 ORFs. By using the bioinformatics suite ERGO, 2,487 (78%) ORFs were assigned functions. The origins of replication of the two chromosomes are similar to those of other alpha-proteobacteria. Housekeeping genes, including those involved in DNA replication, transcription, translation, core metabolism, and cell wall biosynthesis, are distributed on both chromosomes. Type I, II, and III secretion systems are absent, but genes encoding sec-dependent, sec-independent, and flagella-specific type III, type IV, and type V secretion systems as well as adhesins, invasins, and hemolysins were identified. Several features of the B. melitensis genome are similar to those of the symbiotic Sinorhizobium meliloti.Entities:
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Year: 2001 PMID： 11756688 PMCID： PMC117579 DOI： 10.1073/pnas.221575398
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205