Literature DB >> 12058388

Effect of structure on antibiotic action of new 9-(ethylthio)acridines.

K Nesmĕrák1, M Pospisek, B Zikánová, I Nĕmec, J Barbe, J Gabriel.   

Abstract

Six new 9-(ethylthio)acridine derivatives were examined for antibacterial and antifungal activities with 10 bacterial and 8 yeast strains. The only active compounds were 2- and 3-amino derivatives. The observed MICs (mg/L) for 2-amino-9-(ethylthio)acridine (possessing the highest biological activity) were 12 (P. mirabilis), 30 (B. subtillis), 60 (C. freundii), 90 (E. coli), 128 (E. vulneris) and 500 (S. marcescens and S. aureus). Both amino derivatives have also lowest half-wave potential (E1/2) and field Swain-Lupton constants (describing oxidoreduction behavior) what supports the importance of acridine ion formation in the mechanism of antimicrobial action.

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Year:  2002        PMID： 12058388     DOI： 10.1007/bf02817668

Source DB:  PubMed          Journal:  Folia Microbiol (Praha)        ISSN： 0015-5632            Impact factor:   2.099


  10 in total

1.  Physiochemical-activity relations in practice. 1. A rational and self-consistent data bank.

Authors:  F E Norrington; R M Hyde; S G Williams; R Wootton
Journal:  J Med Chem       Date:  1975-06       Impact factor: 7.446

2.  Antifungal properties of substituted 1-phenyl-5-mercaptotetrazoles and their oxidation product, 5-bis-(1-phenyltetrazolyl)disulfide.

Authors:  K Nesmĕrák; M Pospísek; I Nĕmec; K Waisser; J Gabriel
Journal:  Folia Microbiol (Praha)       Date:  2000       Impact factor: 2.099

3.  1,4-Dimethoxy-9(10H)-acridinone derivatives. Synthesis, DNA binding studies and trypanocidal activity.

Authors:  H Berny; N Bsiri; J J Charbit; A M Galy; J C Soyfer; J P Galy; J Barbe; D Sharples; C M Mesa Valle; C Mascaro
Journal:  Arzneimittelforschung       Date:  1992-05

4.  Synthesis of two novel thioacridinic derivatives and comparison of their in vitro biological activities.

Authors:  R Mannani; J P Galy; D Sharples; J Barbe; Y Barra
Journal:  Chem Biol Interact       Date:  1990       Impact factor: 5.192

5.  Antifungal effects of new heterocyclic compounds, 6H-pyrimido[2,1-a]isoindole derivatives.

Authors:  K Nesmĕrák; H Pelouchová; V Vsetecka; I Nĕmec; J Gabriel
Journal:  Folia Microbiol (Praha)       Date:  1998       Impact factor: 2.099

6.  Modified intercalation model for the interaction of amino acridines and DNA.

Authors:  N J Pritchard; A Blake; A R Peacocke
Journal:  Nature       Date:  1966-12-17       Impact factor: 49.962

7.  The influence of chemical constitution on antibacterial activity; a survey of heterocyclic bases, with special reference to benzquinolines, phenanthridines, benzacridines, quinolines and pyridines.

Authors:  A ALBERT; S D RUBBO; M I BURVILL
Journal:  Br J Exp Pathol       Date:  1949-06

8.  Structure-activity relationships and modes of action of 9-anilinoacridines against chloroquine-resistant Plasmodium falciparum in vitro.

Authors:  P Chavalitshewinkoon; P Wilairat; S Gamage; W Denny; D Figgitt; R Ralph
Journal:  Antimicrob Agents Chemother       Date:  1993-03       Impact factor: 5.191

9.  Cytotoxicity of acridine compounds for Leishmania promastigotes in vitro.

Authors:  K A Werbovetz; E K Lehnert; T L Macdonald; R D Pearson
Journal:  Antimicrob Agents Chemother       Date:  1992-02       Impact factor: 5.191

10.  Activity and structure relationship of acridine derivatives against African trypanosomes.

Authors:  W Obexer; C Schmid; J Barbe; J P Galy; R Brun
Journal:  Trop Med Parasitol       Date:  1995-03
  10 in total
  1 in total

1.  Novel 2-Thioxanthine and Dipyrimidopyridine Derivatives: Synthesis and Antimicrobial Activity.

Authors:  Samar El-kalyoubi; Fatmah Agili; Shaker Youssif
Journal:  Molecules       Date:  2015-10-22       Impact factor: 4.411
  1 in total

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