Literature DB >> 9569626

Antifungal effects of new heterocyclic compounds, 6H-pyrimido[2,1-a]isoindole derivatives.

K Nesmĕrák1, H Pelouchová, V Vsetecka, I Nĕmec, J Gabriel.   

Abstract

Minimal inhibitory concentrations for 10 new condensed isoindole derivatives were established by the agar diffusion method. Benzo[b]-6H-pyrimido[2,1-a]isoindole-4-one exhibited a broad antifungal effect; the observed MIC (mg/L) were 7 (K. lactis), 8 (C. pseudotropicalis), 17 (W. fluorescens), 22 (E. magnusii), 31 (P. membranaefaciens), 32 (S. alluvius) and 32 (S. cerevisiae). The compound also inhibited the growth of B. subtilis (MIC 9 mg/L). No effect on the growth of E. coli was found.

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Year:  1998        PMID： 9569626     DOI： 10.1007/BF02815539

Source DB:  PubMed          Journal:  Folia Microbiol (Praha)        ISSN： 0015-5632            Impact factor:   2.099


  7 in total

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Authors:  W P Norred
Journal:  Vet Hum Toxicol       Date:  1990

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Authors:  M Oimomi; M Hamada; T Hara
Journal:  J Antibiot (Tokyo)       Date:  1974-12       Impact factor: 2.649

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Authors:  T H Chan; R K Hill
Journal:  J Org Chem       Date:  1970-10       Impact factor: 4.354

4.  Synthesis, biological evaluation, and quantitative structure-activity relationship analysis of 2-hydroxy-1H-isoindolediones as new cytostatic agents.

Authors:  C L Chan; E J Lien; Z A Tokes
Journal:  J Med Chem       Date:  1987-03       Impact factor: 7.446

5.  Pharmacological properties of SM-3997: a new anxioselective anxiolytic candidate.

Authors:  H Shimizu; A Hirose; T Tatsuno; M Nakamura; J Katsube
Journal:  Jpn J Pharmacol       Date:  1987-12

6.  Nitration of 3-acylindoles in the presence of metal MeCN solvates and synthesis of the antibiotic alkaloid chuangxinmycin.

Authors:  M Murase; T Koike; Y Moriya; S Tobinaga
Journal:  Chem Pharm Bull (Tokyo)       Date:  1987-07       Impact factor: 1.645

7.  Thromboxane synthetase inhibitors and antihypertensive agents. 2. N-[(1H-imidazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones and N-[(1H-1,2,4-triazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones as unique antihypertensive agents.

Authors:  J B Press; W B Wright; P S Chan; J W Marsico; M F Haug; J Tauber; A S Tomcufcik
Journal:  J Med Chem       Date:  1986-05       Impact factor: 7.446
  7 in total
  3 in total

1.  In vitro antimicrobial activity of 3,4-dihydro-s-triazinobenzimidazole derivatives.

Authors:  G Gulyás; T Emri; A Simon; Z Györgydeák
Journal:  Folia Microbiol (Praha)       Date:  2002       Impact factor: 2.099

2.  Antifungal properties of substituted 1-phenyl-5-mercaptotetrazoles and their oxidation product, 5-bis-(1-phenyltetrazolyl)disulfide.

Authors:  K Nesmĕrák; M Pospísek; I Nĕmec; K Waisser; J Gabriel
Journal:  Folia Microbiol (Praha)       Date:  2000       Impact factor: 2.099

3.  Effect of structure on antibiotic action of new 9-(ethylthio)acridines.

Authors:  K Nesmĕrák; M Pospisek; B Zikánová; I Nĕmec; J Barbe; J Gabriel
Journal:  Folia Microbiol (Praha)       Date:  2002       Impact factor: 2.099
  3 in total

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