Literature DB >> 1151976

Physiochemical-activity relations in practice. 1. A rational and self-consistent data bank.

F E Norrington, R M Hyde, S G Williams, R Wootton.   

Abstract

A data bank of substituent constants of 26 ortho and 34 meta and para benzenoid substituents is presented for use in physicochemical-activity relations (PAR) studies. The distributive parameters pri and pri-, a bulk parameter based on molar refraction, and positionally weighted electronic parameters F and R are listed for the three substituent positions. There are no gaps in the table caused by missing values and the interparameter correlation are low.

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Year:  1975        PMID： 1151976     DOI： 10.1021/jm00240a016

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  18 in total

1.  Experimental and theoretical study of the mechanism of hydrolysis of substituted phenyl hexanoates catalysed by globin in the presence of surfactant.

Authors:  Selami Ercan; Nevin Arslan; Safak Ozhan Kocakaya; Necmettin Pirinccioglu; Andrew Williams
Journal:  J Mol Model       Date:  2014-02-22       Impact factor: 1.810

2.  Pattern recognition study of QSAR substituent descriptors.

Authors:  H van de Waterbeemd; N el Tayar; P A Carrupt; B Testa
Journal:  J Comput Aided Mol Des       Date:  1989-06       Impact factor: 3.686

3.  Complexation of nifedipine with substituted phenolic ligands.

Authors:  K M Boje; M Sak; H L Fung
Journal:  Pharm Res       Date:  1988-10       Impact factor: 4.200

4.  Structure-activity studies on nifedipine in isolated cardiac muscle.

Authors:  R Rodenkirchen; R Bayer; R Steiner; F Bossert; H Meyer; E Möller
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-12       Impact factor: 3.000

5.  Effect of structure on antibiotic action of new 9-(ethylthio)acridines.

Authors:  K Nesmĕrák; M Pospisek; B Zikánová; I Nĕmec; J Barbe; J Gabriel
Journal:  Folia Microbiol (Praha)       Date:  2002       Impact factor: 2.099

Review 6.  Partitioning and lipophilicity in quantitative structure-activity relationships.

Authors:  J C Dearden
Journal:  Environ Health Perspect       Date:  1985-09       Impact factor: 9.031

Review 7.  Development of quantitative structure-pharmacokinetic relationships.

Authors:  J M Mayer; H van de Waterbeemd
Journal:  Environ Health Perspect       Date:  1985-09       Impact factor: 9.031

8.  Investigation of Hydro-Lipophilic Properties of N-Alkoxyphenylhydroxynaphthalenecarboxamides †.

Authors:  Iva Kapustikova; Andrzej Bak; Tomas Gonec; Jiri Kos; Violetta Kozik; Josef Jampilek
Journal:  Molecules       Date:  2018-07-04       Impact factor: 4.411

9.  Synthesis, antimycobacterial, antifungal and photosynthesis-inhibiting activity of chlorinated N-phenylpyrazine-2-carboxamides.

Authors:  Martin Dolezal; Jan Zitko; Zdenek Osicka; Jiri Kunes; Marcela Vejsova; Vladimir Buchta; Jiri Dohnal; Josef Jampilek; Katarina Kralova
Journal:  Molecules       Date:  2010-11-26       Impact factor: 4.411

10.  Investigating biological activity spectrum for novel styrylquinazoline analogues.

Authors:  Josef Jampilek; Robert Musiol; Jacek Finster; Matus Pesko; James Carroll; Katarina Kralova; Marcela Vejsova; Jim O'Mahony; Aidan Coffey; Jiri Dohnal; Jaroslaw Polanski
Journal:  Molecules       Date:  2009-10-23       Impact factor: 4.411
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