| Literature DB >> 1530683 |
H Berny1, N Bsiri, J J Charbit, A M Galy, J C Soyfer, J P Galy, J Barbe, D Sharples, C M Mesa Valle, C Mascaro.
Abstract
New acridinonic derivatives, which are hydroxy- and methoxy-substituted in positions 1, 4, and 1,4 were prepared with a view to obtain antiparasitic drugs. These compounds were tested against Trypanosoma cruzi strains and their capability of interacalation into DNA was determined. Nucleus substitutions, DNA binding, and trypanocidal activities have been correlated.Entities:
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Year: 1992 PMID： 1530683
Source DB: PubMed Journal: Arzneimittelforschung ISSN： 0004-4172