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Literature DB >> 11902660

Synthesis and antimicrobial activity of some new hydrazones of 4-fluorobenzoic acid hydrazide and 3-acetyl-2,5-disubstituted-1,3,4-oxadiazolines.

Sevim Rollas¹, Nehir Gulerman, Habibe Erdeniz.

Abstract

A series of hydrazide hydrazones and 1,3,4-oxadiazolines of 4-fluorobenzoic acid hydrazide were prepared and evaluated as potential antimicrobial agents and were tested for their antibacterial and antifungal activities against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. From these compounds, 4-fluorobenzoic acid[(5-nitro-2-furanyl)methylene]hydrazide (1a) showed equal activity with ceftriaxone against S. aureus. In addition, the MIC values of compounds 1c, 1d and 2a for the same strain were in the range of those reported for ceftriaxone according to NCCLS 1997.

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Year: 2002 PMID： 11902660 DOI： 10.1016/s0014-827x(01)01192-2

Source DB: PubMed Journal: Farmaco ISSN： 0014-827X

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Cited

46 in total

1. In vivo metabolism of 2-[1'-phenyl-3'-(3-chlorophenyl)-2'-propenylyden]hydrazino-3-methyl-4(3H)-quinazolinone in rats.

Authors: Bedia Koçyiğit Kaymakçioğlu; Yasemin Aktan; Sibel Süzen; Nesrin Gökhan; Semra Koyunoğlu; Kevser Erol; Akgül Yeşilada; Sevim Rollas
Journal: Eur J Drug Metab Pharmacokinet Date: 2005 Oct-Dec Impact factor: 2.441

Synthesis and antimicrobial activity of some new hydrazones of 4-fluorobenzoic acid hydrazide and 3-acetyl-2,5-disubstituted-1,3,4-oxadiazolines.

1. In vivo metabolism of 2-[1'-phenyl-3'-(3-chlorophenyl)-2'-propenylyden]hydrazino-3-methyl-4(3H)-quinazolinone in rats.

2. Synthesis, anticonvulsant and neurotoxicity evaluation of some new pyrimidine-5-carbonitrile derivatives.

3. In-silico identification of the binding mode of synthesized adamantyl derivatives inside cholinesterase enzymes.

4. HPLC analysis of in vivo metabolites of 4-nitrobenzoic acid [(5-nitro-2-thiopheneyl)methylene]hydrazide in rats.

5. N'-[(E)-4-Bromo-benzyl-idene]-2-(4-isobutyl-phen-yl)propanohydrazide.

6. N'-(2-Hydr-oxy-3-methoxy-benzyl-idene)-1,3-benzodioxole-5-carbohydrazide monohydrate.

7. 1,2-Bis[1-(3-methyl-sulfanyl-1,2,4-triazin-5-yl)ethyl-idene]diazane.

8. 2-(4-Isobutyl-phen-yl)-N'-[1-(4-nitro-phen-yl)ethyl-idene]propanohydrazide.

9. (E)-N'-(2-Hydroxy-benzyl-idene)-2-(4-isobutyl-phen-yl)propanohydrazide.

10. 4-Meth-oxy-N'-(2-methoxy-naphthyl-idene)benzohydrazide.