Literature DB >> 11850279

Antitrypanosomal activities of tryptanthrins.

John Scovill1, Elizabeth Blank, Michael Konnick, Elizabeth Nenortas, Theresa Shapiro.   

Abstract

New drugs and molecular targets are needed against Trypanosoma brucei, the protozoan that causes African sleeping sickness. Tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione), a traditional antifungal agent, and 11 analogs were tested against T. brucei in vitro. The greatest activity was conferred by electron-withdrawing groups in the 8 position of the tryptanthrin ring system; the most potent compound had a 50% effective concentration of 0.40 microM.

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Year:  2002        PMID： 11850279      PMCID： PMC127471          DOI： 10.1128/AAC.46.3.882-883.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  7 in total

1.  High-efficiency clonal growth of bloodstream- and insect-form Trypanosoma brucei on agarose plates.

Authors:  V B Carruthers; G A Cross
Journal:  Proc Natl Acad Sci U S A       Date:  1992-09-15       Impact factor: 11.205

2.  Isolation of antifungal principle tryptanthrin, from Strobilanthes cusia O. Kuntze.

Authors:  G Honda; M Tabata
Journal:  Planta Med       Date:  1979-05       Impact factor: 3.352

3.  Gambiense trypanosomiasis: frequency of, and risk factors for, failure of melarsoprol therapy.

Authors:  J Pépin; F Milord; A Khonde; T Niyonsenga; L Loko; B Mpia
Journal:  Trans R Soc Trop Med Hyg       Date:  1994 Jul-Aug       Impact factor: 2.184

Review 4.  Human African trypanosomiasis: an emerging public health crisis.

Authors:  D H Smith; J Pepin; A H Stich
Journal:  Br Med Bull       Date:  1998       Impact factor: 4.291

5.  Antitrypanosomal activity of camptothecin analogs. Structure-activity correlations.

Authors:  A L Bodley; M C Wani; M E Wall; T A Shapiro
Journal:  Biochem Pharmacol       Date:  1995-09-28       Impact factor: 5.858

6.  Molecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and Leishmania.

Authors:  A L Bodley; T A Shapiro
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-25       Impact factor: 11.205

7.  Drug cytotoxicity assay for African trypanosomes and Leishmania species.

Authors:  A L Bodley; M W McGarry; T A Shapiro
Journal:  J Infect Dis       Date:  1995-10       Impact factor: 5.226
  7 in total
  18 in total

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Authors:  A M Popov; Yu M Gafurov; T V Moskovkina; A V Kachanov; O N Krivoshapko; S E Petrovicheva; V A Stonik
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3.  The Natural Alkaloid Tryptanthrin Induces Apoptosis-like Death in Leishmania spp.

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Journal:  Antimicrob Agents Chemother       Date:  2008-09-29       Impact factor: 5.191

5.  7,9-Dichloro-6H,12H-indolo[2,1-b]quinazoline-6,12-dione.

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Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-05-29

6.  Syntheses of quinazoline-2,4-dione alkaloids and analogues from Mexican Zanthoxylum species.

Authors:  I A Rivero; K Espinoza; R Somanathan
Journal:  Molecules       Date:  2004-06-30       Impact factor: 4.411

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8.  Indole trimers with antibacterial activity against Gram-positive organisms produced using combinatorial biocatalysis.

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9.  Synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives.

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Journal:  Int J Parasitol Drugs Drug Resist       Date:  2015-04-17       Impact factor: 4.077

10.  Trypanocidal activity of thioamide-substituted imidazoquinolinone: electrochemical properties and biological effects.

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