Literature DB >> 18824607

Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs.

Bogdana Krivogorsky1, Peter Grundt, Robert Yolken, Lorraine Jones-Brando.   

Abstract

New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3'-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics.

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Year:  2008        PMID： 18824607      PMCID： PMC2592855          DOI： 10.1128/AAC.00903-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

Review 1.  Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.

Authors:  C A Lipinski; F Lombardo; B W Dominy; P J Feeney
Journal:  Adv Drug Deliv Rev       Date:  2001-03-01       Impact factor: 15.470

2.  Novel indolo[2,1-b]quinazoline analogues as cytostatic agents: synthesis, biological evaluation and structure-activity relationship.

Authors:  Vedula M Sharma; P Prasanna; K V Adi Seshu; B Renuka; C V Laxman Rao; G Sunil Kumar; C Prasad Narasimhulu; P Aravind Babu; R C Puranik; D Subramanyam; A Venkateswarlu; Sriram Rajagopal; K B Sunil Kumar; C Seshagiri Rao; N V S Rao Mamidi; Dhanvanthri S Deevi; R Ajaykumar; R Rajagopalan
Journal:  Bioorg Med Chem Lett       Date:  2002-09-02       Impact factor: 2.823

3.  Cyclin-dependent kinase TPK2 is a critical cell cycle regulator in Toxoplasma gondii.

Authors:  Farzana Khan; Jianzhong Tang; Chang-Le Qin; Kami Kim
Journal:  Mol Microbiol       Date:  2002-07       Impact factor: 3.501

4.  Synthesis of novel 5-substituted indirubins as protein kinases inhibitors.

Authors:  Anne Beauchard; Yoan Ferandin; Stéphane Frère; Olivier Lozach; Mélina Blairvacq; Laurent Meijer; Valérie Thiéry; Thierry Besson
Journal:  Bioorg Med Chem       Date:  2006-06-08       Impact factor: 3.641

5.  Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells.

Authors:  Sangkil Nam; Ralf Buettner; James Turkson; Donghwa Kim; Jin Q Cheng; Stephan Muehlbeyer; Frankie Hippe; Sandra Vatter; Karl-Heinz Merz; Gerhard Eisenbrand; Richard Jove
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-18       Impact factor: 11.205

6.  Antitrypanosomal activities of tryptanthrins.

Authors:  John Scovill; Elizabeth Blank; Michael Konnick; Elizabeth Nenortas; Theresa Shapiro
Journal:  Antimicrob Agents Chemother       Date:  2002-03       Impact factor: 5.191

7.  Analysis of stereoelectronic properties, mechanism of action and pharmacophore of synthetic indolo[2,1-b]quinazoline-6,12-dione derivatives in relation to antileishmanial activity using quantum chemical, cyclic voltammetry and 3-D-QSAR CATALYST procedures.

Authors:  Apurba K Bhattacharjee; David J Skanchy; Barton Jennings; Thomas H Hudson; James J Brendle; Karl A Werbovetz
Journal:  Bioorg Med Chem       Date:  2002-06       Impact factor: 3.641

8.  Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity.

Authors:  Karen M Grant; Morag H Dunion; Vanessa Yardley; Alexios-Leandros Skaltsounis; Doris Marko; Gerhard Eisenbrand; Simon L Croft; Laurent Meijer; Jeremy C Mottram
Journal:  Antimicrob Agents Chemother       Date:  2004-08       Impact factor: 5.191

9.  Structure-activity relationship study of antimalarial indolo [2,1-b]quinazoline-6,12-diones (tryptanthrins). Three dimensional pharmacophore modeling and identification of new antimalarial candidates.

Authors:  Apurba K Bhattacharjee; Mark G Hartell; Daniel A Nichols; Rickey P Hicks; Benjamin Stanton; John E van Hamont; Wilbur K Milhous
Journal:  Eur J Med Chem       Date:  2004-01       Impact factor: 6.514

10.  LC-APCI-MS method for detection and analysis of tryptanthrin, indigo, and indirubin in daqingye and banlangen.

Authors:  Bing-Chung Liau; Ting-Ting Jong; Maw-Rong Lee; Shih-Shiung Chen
Journal:  J Pharm Biomed Anal       Date:  2006-08-01       Impact factor: 3.935
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  12 in total

1.  Thiazole, oxadiazole, and carboxamide derivatives of artemisinin are highly selective and potent inhibitors of Toxoplasma gondii.

Authors:  Christopher P Hencken; Lorraine Jones-Brando; Claudia Bordón; Remo Stohler; Bryan T Mott; Robert Yolken; Gary H Posner; Lauren E Woodard
Journal:  J Med Chem       Date:  2010-05-13       Impact factor: 7.446

2.  Synthesis and antimalarial efficacy of two-carbon-linked, artemisinin-derived trioxane dimers in combination with known antimalarial drugs.

Authors:  Bryan T Mott; Abhai Tripathi; Maxime A Siegler; Cathy D Moore; David J Sullivan; Gary H Posner
Journal:  J Med Chem       Date:  2013-03-07       Impact factor: 7.446

3.  7,9-Dichloro-6H,12H-indolo[2,1-b]quinazoline-6,12-dione.

Authors:  Peter Grundt; Kelsi A Douglas; Bogdana Krivogorsky; Victor N Nemykin
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-05-29

Review 4.  Review of Experimental Compounds Demonstrating Anti-Toxoplasma Activity.

Authors:  Madalyn M McFarland; Sydney J Zach; Xiaofang Wang; Lakshmi-Prasad Potluri; Andrew J Neville; Jonathan L Vennerstrom; Paul H Davis
Journal:  Antimicrob Agents Chemother       Date:  2016-11-21       Impact factor: 5.191

5.  Synthesis, biological evaluation, and molecular modeling of 11H-indeno[1,2-b]quinoxalin-11-one derivatives and tryptanthrin-6-oxime as c-Jun N-terminal kinase inhibitors.

Authors:  Igor A Schepetkin; Andrei I Khlebnikov; Andrei S Potapov; Anastasia R Kovrizhina; Vladislava V Matveevskaya; Maxim L Belyanin; Dmitriy N Atochin; Svitlana O Zanoza; Nadiya M Gaidarzhy; Sergiy A Lyakhov; Liliya N Kirpotina; Mark T Quinn
Journal:  Eur J Med Chem       Date:  2018-10-12       Impact factor: 6.514

6.  Indole trimers with antibacterial activity against Gram-positive organisms produced using combinatorial biocatalysis.

Authors:  Kevin McClay; Shahila Mehboob; Jerry Yu; Bernard D Santarsiero; Jiangping Deng; James L Cook; Hyunyoung Jeong; Michael E Johnson; Robert J Steffan
Journal:  AMB Express       Date:  2015-06-26       Impact factor: 3.298

7.  Synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives.

Authors:  Liliane Abodo Onambele; Herbert Riepl; Rainer Fischer; Gabriele Pradel; Aram Prokop; Makoah Nigel Aminake
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2015-04-17       Impact factor: 4.077

8.  The synthetic tryptanthrin analogue suppresses STAT3 signaling and induces caspase dependent apoptosis via ERK up regulation in human leukemia HL-60 cells.

Authors:  Anup S Pathania; Suresh Kumar; Santosh K Guru; Shashi Bhushan; Parduman R Sharma; Sravan K Aithagani; Parvinder P Singh; Ram A Vishwakarma; Ajay Kumar; Fayaz Malik
Journal:  PLoS One       Date:  2014-11-10       Impact factor: 3.240

Review 9.  Drugs in development for toxoplasmosis: advances, challenges, and current status.

Authors:  P Holland Alday; Joseph Stone Doggett
Journal:  Drug Des Devel Ther       Date:  2017-01-25       Impact factor: 4.162

10.  Trypanocidal activity of thioamide-substituted imidazoquinolinone: electrochemical properties and biological effects.

Authors:  Fernanda M Frank; Alejandra B Ciccarelli; Mariela Bollini; Ana M Bruno; Alcira Batlle; Maria E Lombardo
Journal:  Evid Based Complement Alternat Med       Date:  2013-07-08       Impact factor: 2.629
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