Literature DB >> 26577113

Facile microwave-assisted synthesis of benzimidazole scaffolds via Ugi-type three-component condensation (3CC) reactions.

Gui-Ting Song1,2,3, Zhi-Gang Xu1, Dian-Yong Tang1, Shi-Qiang Li1, Zhi-Gang Xie1, Hong-Liang Zhong1, Zhi-Wei Yang1, Jin Zhu2, Jin Zhang4, Zhong-Zhu Chen5.   

Abstract

Two series of fused benzimidazoles were synthesized via a facile, one-pot procedure under microwave irradiation. This procedure generated the desired products in high yields and could provide a useful synthetic platform with potential applications in medicinal chemistry.

Entities:  

Keywords:  Benzimidazole; Cyclization; Groebke–Blackburn reaction; Microwave irradiation; Multicomponent reactions (MCRs); Three-component condensation (3-CC)

Mesh：

Substances：

Year:  2015        PMID： 26577113     DOI： 10.1007/s11030-015-9646-7

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  18 in total

1.  Towards molecular diversity: dealkylation of tert-butyl amine in Ugi-type multicomponent reaction product establishes tert-butyl isocyanide as a useful convertible isonitrile.

Authors:  Sankar K Guchhait; Chetna Madaan
Journal:  Org Biomol Chem       Date:  2010-06-24       Impact factor: 3.876

2.  Imidazole derivatives: a comprehensive survey of their recognition properties.

Authors:  Pedro Molina; Alberto Tárraga; Francisco Otón
Journal:  Org Biomol Chem       Date:  2012-01-27       Impact factor: 3.876

3.  Rapid synthesis of 3-amino-imidazopyridines by a microwave-assisted four-component coupling in one pot.

Authors:  Erin F Dimauro; Joseph M Kennedy
Journal:  J Org Chem       Date:  2007-02-02       Impact factor: 4.354

4.  Palladium-catalyzed selective dehydrogenative cross-couplings of heteroarenes.

Authors:  Xavier Bugaut; Frank Glorius
Journal:  Angew Chem Int Ed Engl       Date:  2011-07-08       Impact factor: 15.336

5.  Facile, novel two-step syntheses of benzimidazoles, bis-benzimidazoles, and bis-benzimidazole-dihydroquinoxalines.

Authors:  Zhigang Xu; Arthur Y Shaw; Justin Dietrich; Alexandra P Cappelli; Gary Nichol; Christopher Hulme
Journal:  Mol Divers       Date:  2012-01-12       Impact factor: 2.943

6.  Palladium-catalyzed oxidative cross-coupling between pyridine N-oxides and indoles.

Authors:  Xue Gong; Guoyong Song; Hong Zhang; Xingwei Li
Journal:  Org Lett       Date:  2011-03-09       Impact factor: 6.005

7.  Antitrypanosomal activities of tryptanthrins.

Authors:  John Scovill; Elizabeth Blank; Michael Konnick; Elizabeth Nenortas; Theresa Shapiro
Journal:  Antimicrob Agents Chemother       Date:  2002-03       Impact factor: 5.191

8.  One-pot sequential C-N coupling and cross dehydrogenative couplings: synthesis of novel azole fused imidazo[1,2-a]pyridines.

Authors:  Kasiviswanadharaju Pericherla; Poonam Khedar; Bharti Khungar; Anil Kumar
Journal:  Chem Commun (Camb)       Date:  2013-04-11       Impact factor: 6.222

9.  New potent imidazoisoquinolinone derivatives as anti-Trypanosoma cruzi agents: biological evaluation and structure-activity relationships.

Authors:  Mariela Bollini; Juan José Casal; Diego E Alvarez; Lucía Boiani; Mercedes González; Hugo Cerecetto; Ana María Bruno
Journal:  Bioorg Med Chem       Date:  2009-01-15       Impact factor: 3.641

10.  Synthesis, anti-inflammatory, and antiproliferative activity evaluation of isoindole, pyrrolopyrazine, benzimidazoisoindole, and benzimidazopyrrolopyrazine derivatives.

Authors:  Sandeep Kumar; Nikhil Kumar; Partha Roy; Sham M Sondhi
Journal:  Mol Divers       Date:  2013-08-27       Impact factor: 2.943
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