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Literature DB >> 11847285

Short-chain dehydrogenase/reductase (SDR) relationships: a large family with eight clusters common to human, animal, and plant genomes.

Yvonne Kallberg¹, Udo Oppermann, Hans Jörnvall, Bengt Persson.

Abstract

The progress in genome characterizations has opened new routes for studying enzyme families. The availability of the human genome enabled us to delineate the large family of short-chain dehydrogenase/reductase (SDR) members. Although the human genome releases are not yet final, we have already found 63 members. We have also compared these SDR forms with those of three model organisms: Caenorhabditis elegans, Drosophila melanogaster, and Arabidopsis thaliana. We detect eight SDR ortholog clusters in a cross-genome comparison. Four of these clusters represent extended SDR forms, a subgroup found in all life forms. The other four are classical SDRs with activities involved in cellular differentiation and signalling. We also find 18 SDR genes that are present only in the human genome of the four genomes studied, reflecting enzyme forms specific to mammals. Close to half of these gene products represent steroid dehydrogenases, emphasizing the regulatory importance of these enzymes.

Entities: Species

Mesh：

Substances：
Oxidoreductases

Year: 2002 PMID： 11847285 PMCID： PMC2373483 DOI： 10.1110/ps.26902

Source DB: PubMed Journal: Protein Sci ISSN： 0961-8368 Impact factor: 6.725

37 in total

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Journal: J Biol Chem Date: 2001-03-08 Impact factor: 5.157

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Authors: U C Oppermann; C Filling; H Jörnvall
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Journal: Nature Date: 2001-02-15 Impact factor: 49.962

Review 4. "Don't know much bile-ology".

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Journal: Cell Date: 2000-09-29 Impact factor: 41.582

Review 5. Metabolic conversion as a pre-receptor control mechanism for lipophilic hormones.

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Journal: Eur J Biochem Date: 2001-08

6. Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium.

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Journal: Cancer Res Date: 2001-02-15 Impact factor: 12.701

7. Improved tools for biological sequence comparison.

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Journal: Proc Natl Acad Sci U S A Date: 1988-04 Impact factor: 11.205

Review 8. Oxysterol biosynthetic enzymes.

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Journal: Biochim Biophys Acta Date: 2000-12-15

9. The Arabidopsis Information Resource (TAIR): a comprehensive database and web-based information retrieval, analysis, and visualization system for a model plant.

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Journal: Nucleic Acids Res Date: 2001-01-01 Impact factor: 16.971

10. The sequence of the human genome.

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Journal: Science Date: 2001-02-16 Impact factor: 47.728

61 in total

Review 1. Alcohol and aldehyde dehydrogenases: retinoid metabolic effects in mouse knockout models.

Authors: Sandeep Kumar; Lisa L Sandell; Paul A Trainor; Frank Koentgen; Gregg Duester
Journal: Biochim Biophys Acta Date: 2011-04-15

2. Crystallization of an atypical short-chain dehydrogenase from Vibrio vulnificus lacking the conserved catalytic tetrad.

Authors: Geraldine Buysschaert; Kenneth Verstraete; Savvas N Savvides; Bjorn Vergauwen
Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun Date: 2012-06-27

3. Structural insight into substrate differentiation of the sugar-metabolizing enzyme galactitol dehydrogenase from Rhodobacter sphaeroides D.

Authors: Yvonne Carius; Henning Christian; Annette Faust; Ulrich Zander; Björn U Klink; Petra Kornberger; Gert-Wieland Kohring; Friedrich Giffhorn; Axel J Scheidig
Journal: J Biol Chem Date: 2010-04-21 Impact factor: 5.157

4. WWOX protein expression in normal human tissues.

Authors: Maria I Nunez; John Ludes-Meyers; C Marcelo Aldaz
Journal: J Mol Histol Date: 2006-08-29 Impact factor: 2.611

5. Analysis of ESTs from Lutzomyia longipalpis sand flies and their contribution toward understanding the insect-parasite relationship.

Authors: Rod J Dillon; Al C Ivens; Carol Churcher; Nancy Holroyd; Michael A Quail; Matthew E Rogers; M Bento Soares; Maria F Bonaldo; Thomas L Casavant; Mike J Lehane; Paul A Bates
Journal: Genomics Date: 2006-08-01 Impact factor: 5.736

10. Structure and mechanism of a bacterial haloalcohol dehalogenase: a new variation of the short-chain dehydrogenase/reductase fold without an NAD(P)H binding site.

Authors: R M de Jong; J J W Tiesinga; H J Rozeboom; K H Kalk; L Tang; D B Janssen; B W Dijkstra
Journal: EMBO J Date: 2003-10-01 Impact factor: 11.598