| Literature DB >> 18949601 |
Oleg A Barski1, Srinivas M Tipparaju, Aruni Bhatnagar.
Abstract
The aldo-keto reductase (AKR) superfamily comprises enzymes that catalyze redox transformations involved in biosynthesis, intermediary metabolism, and detoxification. Substrates of AKRs include glucose, steroids, glycosylation end-products, lipid peroxidation products, and environmental pollutants. These proteins adopt a (beta/alpha)(8) barrel structural motif interrupted by a number of extraneous loops and helixes that vary between proteins and bring structural identity to individual families. The human AKR family differs from the rodent families. Due to their broad substrate specificity, AKRs play an important role in the phase II detoxification of a large number of pharmaceuticals, drugs, and xenobiotics.Entities:
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Year: 2008 PMID： 18949601 PMCID： PMC2663408 DOI： 10.1080/03602530802431439
Source DB: PubMed Journal: Drug Metab Rev ISSN： 0360-2532 Impact factor: 4.518