Literature DB >> 11836102

Influence of 2-substituent on the activity of imidazo[1,2-a] pyridine derivatives against human cytomegalovirus.

Sylvie Mavel1, Jean-Louis Renou, Christophe Galtier, Hassan Allouchi, Robert Snoeck, Graciella Andrei, Erik De Clercq, Jan Balzarini, Alain Gueiffier.   

Abstract

The synthesis of various 2-substituted imidazo[1,2-a]pyridine bearing a thioether side chain in position 3 was reported. The new compounds were characterized by 1H and 13C NMR spectra. A conformational study was obtained by X-ray crystallographic analysis for 2-biphen-4-ylimidazopyridine 7. The antiviral activity against human cytomegalovirus (HCMV) was investigated. It was strongly influenced by the nature of C-2 substituent.

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Year:  2002        PMID： 11836102     DOI： 10.1016/s0968-0896(01)00347-9

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  9 in total

1.  Electro-organic synthesis of tetrahydroimidazo[1,2-a]pyridin-5(1H)-one via a multicomponent reaction.

Authors:  Mohammad Reza Asghariganjeh; Ali Asghar Mohammadi; Elham Tahanpesar; Ayeh Rayatzadeh; Somayeh Makarem
Journal:  Mol Divers       Date:  2020-01-09       Impact factor: 2.943

2.  N-(2-Phenyl-imidazo[1,2-a]pyridin-3-yl)acetamide.

Authors:  Abderrahmane Anaflous; Hanane Albay; Nour-Eddine Benchat; Brahim El Bali; Michal Dušek; Karla Fejfarová
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-04-26

3.  Ethyl 8-amino-6-bromoimidazo[1,2-a]pyridine-2-carb-oxy-late.

Authors:  Siham Dahmani; Youssef Kandri Rodi; Santiago V Luis; El Mokhtar Essassi; Lahcen El Ammari
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-05-11

4.  2-(Morpholin-4-yl)-6-(1H-pyrrol-1-yl)-pyridine-3,5-dicarbonitrile.

Authors:  Peter N Horton; Shaaban K Mohamed; Ahmed M Soliman; Eman M M Abdel-Raheem; Mehmet Akkurt
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-02-29

5.  5-Bromo-N-(3,4-dimeth-oxy-benz-yl)pyridin-2-amine.

Authors:  Jie Li; Lin-Yan Lu; Wang-Xing Shen; Jian-You Shi
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-04-18

6.  Synthesis, Characterization and Antibacterial Activity of some Novel Thiosemicarbazides, 1,2,4-Triazol-3-thiols and their S-substituted Derivatives.

Authors:  Mehdi Kalhor; Mahboobeh Shabani; Iraj Nikokar; Seyedeh Reyhaneh Banisaeed
Journal:  Iran J Pharm Res       Date:  2015       Impact factor: 1.696

7.  Synthesis, biological evaluation and molecular docking studies of 6-(4-nitrophenoxy)-1H-imidazo[4,5-b]pyridine derivatives as novel antitubercular agents: future DprE1 inhibitors.

Authors:  Jineetkumar Gawad; Chandrakant Bonde
Journal:  Chem Cent J       Date:  2018-12-19       Impact factor: 4.215

8.  Crystal structure, DFT calculation, Hirshfeld surface analysis and energy framework study of 6-bromo-2-(4-bromo-phen-yl)imidazo[1,2-a]pyridine.

Authors:  Hussien Ahmed Khamees; Kumara Chaluvaiah; Nasseem Ahmed El-Khatatneh; Ananda Swamynayaka; Kwong Huey Chong; Jagadeesh Prasad Dasappa; Mahendra Madegowda
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-10-03

9.  Isotypic crystal structures of 1-benzyl-4-(4-bromo-phen-yl)-2-imino-1,2,5,6,7,8,9,10-octa-hydro-cyclo-octa-[b]pyridine-3-carbo-nitrile and 1-benzyl-4-(4-fluoro-phen-yl)-2-imino-1,2,5,6,7,8,9,10-octa-hydro-cyclo-octa-[b]pyridine-3-carbo-nitrile.

Authors:  R A Nagalakshmi; J Suresh; S Maharani; R Ranjith Kumar; P L Nilantha Lakshman
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-10-18
  9 in total

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