Literature DB >> 11782312

Rca1 inhibits APC-Cdh1(Fzr) and is required to prevent cyclin degradation in G2.

Ruth Grosskortenhaus1, Frank Sprenger.   

Abstract

We demonstrate that Rca1 is an essential inhibitor of the anaphase-promoting complex/cyclosome (APC) in Drosophila. APC activity is restricted to mitotic stages and G1 by its activators Cdc20-Fizzy (Cdc20(Fzy)) and Cdh1-Fizzy-related (Cdh1(Fzr)), respectively. In rca1 mutants, cyclins are degraded prematurely in G2 by APC-Cdh1(Fzr)-dependent proteolysis, and cells fail to execute mitosis. Overexpression of Cdh1(Fzr) mimics the rca1 phenotype, and coexpression of Rca1 blocks this Cdh1(Fzr) function. We show that Rca1 and Cdh1(Fzr) are in a complex that also includes the APC component Cdc27. Previous studies have shown that phosphorylation of Cdh1 prevents its interaction with the APC. Our data reveal a different mode of APC regulation by Rca1 at the G2 stage, when low Cdk activity is unable to inhibit Cdh1(Fzr) interaction.

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Year:  2002        PMID： 11782312     DOI： 10.1016/s1534-5807(01)00104-6

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  49 in total

1.  Arabidopsis ULTRAVIOLET-B-INSENSITIVE4 maintains cell division activity by temporal inhibition of the anaphase-promoting complex/cyclosome.

Authors:  Jefri Heyman; Hilde Van den Daele; Kevin De Wit; Véronique Boudolf; Barbara Berckmans; Aurine Verkest; Claire Lessa Alvim Kamei; Geert De Jaeger; Csaba Koncz; Lieven De Veylder
Journal:  Plant Cell       Date:  2011-12-13       Impact factor: 11.277

2.  GIGAS CELL1, a novel negative regulator of the anaphase-promoting complex/cyclosome, is required for proper mitotic progression and cell fate determination in Arabidopsis.

Authors:  Eriko Iwata; Saki Ikeda; Sachihiro Matsunaga; Mariko Kurata; Yasushi Yoshioka; Marie-Claire Criqui; Pascal Genschik; Masaki Ito
Journal:  Plant Cell       Date:  2011-12-13       Impact factor: 11.277

3.  Degradation of origin recognition complex large subunit by the anaphase-promoting complex in Drosophila.

Authors:  Marito Araki; Robin P Wharton; Zhanyun Tang; Hongtao Yu; Maki Asano
Journal:  EMBO J       Date:  2003-11-17       Impact factor: 11.598

Review 4.  APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.

Authors:  Xinxian Qiao; Liyong Zhang; Armin M Gamper; Takeo Fujita; Yong Wan
Journal:  Cell Cycle       Date:  2010-10-11       Impact factor: 4.534

Review 5.  Putting CENP-A in its place.

Authors:  Madison E Stellfox; Aaron O Bailey; Daniel R Foltz
Journal:  Cell Mol Life Sci       Date:  2012-06-23       Impact factor: 9.261

Review 6.  The emerging role of APC/CCdh1 in development.

Authors:  Dong Hu; Xinxian Qiao; George Wu; Yong Wan
Journal:  Semin Cell Dev Biol       Date:  2011-04-07       Impact factor: 7.727

7.  Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1.

Authors:  Maria Enquist-Newman; Matt Sullivan; David O Morgan
Journal:  Mol Cell       Date:  2008-05-23       Impact factor: 17.970

Review 8.  Regulation of APC/C activators in mitosis and meiosis.

Authors:  Jillian A Pesin; Terry L Orr-Weaver
Journal:  Annu Rev Cell Dev Biol       Date:  2008       Impact factor: 13.827

9.  Novel functions of plant cyclin-dependent kinase inhibitors, ICK1/KRP1, can act non-cell-autonomously and inhibit entry into mitosis.

Authors:  Christina Weinl; Sebastian Marquardt; Suzanne J H Kuijt; Moritz K Nowack; Marc J Jakoby; Martin Hülskamp; Arp Schnittger
Journal:  Plant Cell       Date:  2005-03-04       Impact factor: 11.277

10.  Human T-lymphotropic virus type 1 oncoprotein tax promotes unscheduled degradation of Pds1p/securin and Clb2p/cyclin B1 and causes chromosomal instability.

Authors:  Baoying Liu; Min-Hui Liang; Yu-liang Kuo; Wei Liao; Imre Boros; Tami Kleinberger; Jan Blancato; Chou-Zen Giam
Journal:  Mol Cell Biol       Date:  2003-08       Impact factor: 4.272
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