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Literature DB >> 18598214

Regulation of APC/C activators in mitosis and meiosis.

Abstract

The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit E3 ubiquitin ligase that triggers the degradation of multiple substrates during mitosis. Cdc20/Fizzy and Cdh1/Fizzy-related activate the APC/C and confer substrate specificity through complex interactions with both the core APC/C and substrate proteins. The regulation of Cdc20 and Cdh1 is critical for proper APC/C activity and occurs in multiple ways: targeted protein degradation, phosphorylation, and direct binding of inhibitory proteins. During the specialized divisions of meiosis, the activity of the APC/C must be modified to achieve proper chromosome segregation. Recent studies show that one way in which APC/C activity is modified is through the use of meiosis-specific APC/C activators. Furthermore, regulation of the APC/C during meiosis is carried out by both mitotic regulators of the APC/C as well as meiosis-specific regulators. Here, we review the regulation of APC/C activators during mitosis and the role and regulation of the APC/C during female meiosis.

Entities: Disease Gene

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Year: 2008 PMID： 18598214 PMCID： PMC4070676 DOI： 10.1146/annurev.cellbio.041408.115949

Source DB: PubMed Journal: Annu Rev Cell Dev Biol ISSN： 1081-0706 Impact factor: 13.827

130 in total

1. Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1.

Authors: David V Hansen; Alexander V Loktev; Kenneth H Ban; Peter K Jackson
Journal: Mol Biol Cell Date: 2004-10-06 Impact factor: 4.138

Review 2. Meiosis: cell-cycle controls shuffle and deal.

Authors: Adèle L Marston; Angelika Amon
Journal: Nat Rev Mol Cell Biol Date: 2004-12 Impact factor: 94.444

3. Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint.

Authors: Zhanyun Tang; Hongjun Shu; Dilhan Oncel; She Chen; Hongtao Yu
Journal: Mol Cell Date: 2004-11-05 Impact factor: 17.970

4. Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity.

Authors: Andreas Schmidt; Peter I Duncan; Nadine R Rauh; Guido Sauer; Andrew M Fry; Erich A Nigg; Thomas U Mayer
Journal: Genes Dev Date: 2005-02-15 Impact factor: 11.361

5. The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1.

Authors: Tobias Oelschlaegel; Martin Schwickart; Joao Matos; Aliona Bogdanova; Alain Camasses; Jan Havlis; Andrej Shevchenko; Wolfgang Zachariae
Journal: Cell Date: 2005-03-25 Impact factor: 41.582

6. The Cdc20 (Fzy)/Cdh1-related protein, Cort, cooperates with Fzy in cyclin destruction and anaphase progression in meiosis I and II in Drosophila.

Authors: Andrew Swan; Trudi Schüpbach
Journal: Development Date: 2007-01-24 Impact factor: 6.868

7. Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p.

Authors: Daisuke Izawa; Masuo Goto; Akira Yamashita; Hiroyuki Yamano; Masayuki Yamamoto
Journal: Nature Date: 2005-03-24 Impact factor: 49.962

8. Mnd2, an essential antagonist of the anaphase-promoting complex during meiotic prophase.

Authors: Alexandra M Penkner; Susanne Prinz; Stefan Ferscha; Franz Klein
Journal: Cell Date: 2005-03-25 Impact factor: 41.582

9. The meiotic defects of mutants in the Drosophila mps1 gene reveal a critical role of Mps1 in the segregation of achiasmate homologs.

Authors: William D Gilliland; Sarah M Wayson; R Scott Hawley
Journal: Curr Biol Date: 2005-04-12 Impact factor: 10.834

10. The spindle assembly checkpoint is not essential for CSF arrest of mouse oocytes.

Authors: Chizuko Tsurumi; Steffen Hoffmann; Stephan Geley; Ralph Graeser; Zbigniew Polanski
Journal: J Cell Biol Date: 2004-12-20 Impact factor: 10.539

152 in total

1. A genetic model for the female sterility barrier between Asian and African cultivated rice species.

Authors: Andrea Garavito; Romain Guyot; Jaime Lozano; Frédérick Gavory; Sylvie Samain; Olivier Panaud; Joe Tohme; Alain Ghesquière; Mathias Lorieux
Journal: Genetics Date: 2010-05-10 Impact factor: 4.562

2. GIGAS CELL1, a novel negative regulator of the anaphase-promoting complex/cyclosome, is required for proper mitotic progression and cell fate determination in Arabidopsis.

Authors: Eriko Iwata; Saki Ikeda; Sachihiro Matsunaga; Mariko Kurata; Yasushi Yoshioka; Marie-Claire Criqui; Pascal Genschik; Masaki Ito
Journal: Plant Cell Date: 2011-12-13 Impact factor: 11.277

10. Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability.

Authors: Christiane Hassel; Bingqing Zhang; Michael Dixon; Brian R Calvi
Journal: Development Date: 2013-11-27 Impact factor: 6.868

Regulation of APC/C activators in mitosis and meiosis.

1. Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1.

Review 2. Meiosis: cell-cycle controls shuffle and deal.

3. Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint.

4. Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity.

5. The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1.

6. The Cdc20 (Fzy)/Cdh1-related protein, Cort, cooperates with Fzy in cyclin destruction and anaphase progression in meiosis I and II in Drosophila.

7. Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p.

8. Mnd2, an essential antagonist of the anaphase-promoting complex during meiotic prophase.

9. The meiotic defects of mutants in the Drosophila mps1 gene reveal a critical role of Mps1 in the segregation of achiasmate homologs.

10. The spindle assembly checkpoint is not essential for CSF arrest of mouse oocytes.

1. A genetic model for the female sterility barrier between Asian and African cultivated rice species.

2. GIGAS CELL1, a novel negative regulator of the anaphase-promoting complex/cyclosome, is required for proper mitotic progression and cell fate determination in Arabidopsis.

3. Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism.

4. Depletion of p31comet protein promotes sensitivity to antimitotic drugs.

5. Cullin 4-ring finger-ligase plays a key role in the control of endoreplication cycles in Arabidopsis trichomes.

6. Amyloid β-induced FOXRED2 mediates neuronal cell death via inhibition of proteasome activity.

Review 7. Substrate-specific regulation of ubiquitination by the anaphase-promoting complex.

Review 8. APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.

Review 9. Decision for cell fate: deubiquitinating enzymes in cell cycle checkpoint.

10. Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability.