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Literature DB >> 20935501

APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.

Xinxian Qiao¹, Liyong Zhang, Armin M Gamper, Takeo Fujita, Yong Wan.

Abstract

Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets various substrates for proteolysis inside and outside of the cell cycle. The activation of APC/C is dependent on two WD-40 domain proteins, Cdc20 and Cdh1. While APC/Cdc20 principally regulates mitotic progression, APC/Cdh1 shows a broad spectrum of substrates in and beyond cell cycle. In the past several years, numerous biochemical and mouse genetic studies have greatly attracted our attention to the emerging role of APC/Cdh1 in genomic integrity, cellular differentiation and human diseases. This review will aim to summarize the recently expanded understanding of APC/Cdh1 in regulating biological function and how its dysfunction may lead to diseases.

Entities: Gene Species

Mesh：

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Year: 2010 PMID： 20935501 PMCID： PMC3047751 DOI： 10.4161/cc.9.19.13585

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

75 in total

1. TGFbeta-Smad2 signaling regulates the Cdh1-APC/SnoN pathway of axonal morphogenesis.

Authors: Judith Stegmüller; Mai Anh Huynh; Zengqiang Yuan; Yoshiyuki Konishi; Azad Bonni
Journal: J Neurosci Date: 2008-02-20 Impact factor: 6.167

2. Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth.

Authors: Anna Lasorella; Judith Stegmüller; Daniele Guardavaccaro; Guangchao Liu; Maria S Carro; Gerson Rothschild; Luis de la Torre-Ubieta; Michele Pagano; Azad Bonni; Antonio Iavarone
Journal: Nature Date: 2006-06-28 Impact factor: 49.962

3. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

Authors: M Serrano; A W Lin; M E McCurrach; D Beach; S W Lowe
Journal: Cell Date: 1997-03-07 Impact factor: 41.582

4. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1.

Authors: G Fang; H Yu; M W Kirschner
Journal: Mol Cell Date: 1998-08 Impact factor: 17.970

5. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers.

Authors: Scott L Carter; Aron C Eklund; Isaac S Kohane; Lyndsay N Harris; Zoltan Szallasi
Journal: Nat Genet Date: 2006-08-20 Impact factor: 38.330

6. Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma.

Authors: Hung-Wei Pan; Han-Yi E Chou; Shu-Hsiang Liu; Shian-Yang Peng; Chao-Lien Liu; Hey-Chi Hsu
Journal: Cell Cycle Date: 2006-11-15 Impact factor: 4.534

7. A p53-dependent checkpoint pathway prevents rereplication.

Authors: Cyrus Vaziri; Sandeep Saxena; Yesu Jeon; Charles Lee; Kazutaka Murata; Yuichi Machida; Nikhil Wagle; Deog Su Hwang; Anindya Dutta
Journal: Mol Cell Date: 2003-04 Impact factor: 17.970

8. The ubiquitin ligase APC(Cdh1) is required to maintain genome integrity in primary human cells.

Authors: D Engelbert; D Schnerch; A Baumgarten; R Wäsch
Journal: Oncogene Date: 2007-08-13 Impact factor: 9.867

Review 9. The spindle-assembly checkpoint in space and time.

Authors: Andrea Musacchio; Edward D Salmon
Journal: Nat Rev Mol Cell Biol Date: 2007-04-11 Impact factor: 94.444

10. Akt finds its new path to regulate cell cycle through modulating Skp2 activity and its destruction by APC/Cdh1.

Authors: Daming Gao; Hiroyuki Inuzuka; Alan Tseng; Wenyi Wei
Journal: Cell Div Date: 2009-06-23 Impact factor: 5.130

50 in total

Review 1. Genetic alterations of PTEN in human melanoma.

Authors: Almass-Houd Aguissa-Touré; Gang Li
Journal: Cell Mol Life Sci Date: 2011-11-11 Impact factor: 9.261

Review 2. Insights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle.

Authors: Xiomaris M Cotto-Rios; Mathew J K Jones; Tony T Huang
Journal: Cell Cycle Date: 2011-12-01 Impact factor: 4.534

3. The role of APC/C(Cdh1) in replication stress and origin of genomic instability.

Authors: C Greil; J Krohs; D Schnerch; M Follo; J Felthaus; M Engelhardt; R Wäsch
Journal: Oncogene Date: 2015-10-12 Impact factor: 9.867

Review 4. The emerging role of APC/CCdh1 in development.

Authors: Dong Hu; Xinxian Qiao; George Wu; Yong Wan
Journal: Semin Cell Dev Biol Date: 2011-04-07 Impact factor: 7.727

5. The anaphase promoting complex promotes NHEJ repair through stabilizing Ku80 at DNA damage sites.

Authors: Chengxian Ma; Kyungsoo Ha; Min-Su Kim; Young-Woock Noh; Han Lin; Lichun Tang; Qing Zhu; Dan Zhang; Huan Chen; Suxia Han; Pumin Zhang
Journal: Cell Cycle Date: 2018-07-18 Impact factor: 4.534

6. REV7 is required for anaphase-promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1.

Authors: Abel Chiu-Shun Chun; Kin-Hang Kok; Dong-Yan Jin
Journal: Cell Cycle Date: 2012-01-15 Impact factor: 4.534