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Literature DB >> 22729156

Putting CENP-A in its place.

Madison E Stellfox¹, Aaron O Bailey, Daniel R Foltz.

Abstract

The centromere is the chromosomal region that directs kinetochore assembly during mitosis in order to facilitate the faithful segregation of sister chromatids. The location of the human centromere is epigenetically specified. The presence of nucleosomes that contain the histone H3 variant, CENP-A, are thought to be the epigenetic mark that indicates active centromeres. Maintenance of centromeric identity requires the deposition of new CENP-A nucleosomes with each cell cycle. During S-phase, existing CENP-A nucleosomes are divided among the daughter chromosomes, while new CENP-A nucleosomes are deposited during early G1. The specific assembly of CENP-A nucleosomes at centromeres requires the Mis18 complex, which recruits the CENP-A assembly factor, HJURP. We will review the unique features of centromeric chromatin as well as the mechanism of CENP-A nucleosome deposition. We will also highlight a few recent discoveries that begin to elucidate the factors that temporally and spatially control CENP-A deposition.

Entities: CellLine Chemical Disease Gene Species

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Year: 2012 PMID： 22729156 PMCID： PMC4084702 DOI： 10.1007/s00018-012-1048-8

Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261

155 in total

1. Partitioning and plasticity of repressive histone methylation states in mammalian chromatin.

Authors: Antoine H F M Peters; Stefan Kubicek; Karl Mechtler; Roderick J O'Sullivan; Alwin A H A Derijck; Laura Perez-Burgos; Alexander Kohlmaier; Susanne Opravil; Makoto Tachibana; Yoichi Shinkai; Joost H A Martens; Thomas Jenuwein
Journal: Mol Cell Date: 2003-12 Impact factor: 17.970

2. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells.

Authors: Hiroshi Izuta; Masashi Ikeno; Nobutaka Suzuki; Takeshi Tomonaga; Naohito Nozaki; Chikashi Obuse; Yasutomo Kisu; Naoki Goshima; Fumio Nomura; Nobuo Nomura; Kinya Yoda
Journal: Genes Cells Date: 2006-06 Impact factor: 1.891

3. The Stability of Broken Ends of Chromosomes in Zea Mays.

Authors: B McClintock
Journal: Genetics Date: 1941-03 Impact factor: 4.562

4. Epigenetic engineering: histone H3K9 acetylation is compatible with kinetochore structure and function.

Authors: Jan H Bergmann; Julia N Jakubsche; Nuno M Martins; Alexander Kagansky; Megumi Nakano; Hiroshi Kimura; David A Kelly; Bryan M Turner; Hiroshi Masumoto; Vladimir Larionov; William C Earnshaw
Journal: J Cell Sci Date: 2012-02-13 Impact factor: 5.285

5. A small GTPase molecular switch regulates epigenetic centromere maintenance by stabilizing newly incorporated CENP-A.

Authors: Anaïck Lagana; Jonas F Dorn; Valérie De Rop; Anne-Marie Ladouceur; Amy S Maddox; Paul S Maddox
Journal: Nat Cell Biol Date: 2010-11-21 Impact factor: 28.824

6. Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP.

Authors: Hao Hu; Yang Liu; Mingzhu Wang; Junnan Fang; Hongda Huang; Na Yang; Yanbo Li; Jianyu Wang; Xuebiao Yao; Yunyu Shi; Guohong Li; Rui-Ming Xu
Journal: Genes Dev Date: 2011-04-08 Impact factor: 11.361

Review 7. "Holo"er than thou: chromosome segregation and kinetochore function in C. elegans.

Authors: Paul S Maddox; Karen Oegema; Arshad Desai; Iain M Cheeseman
Journal: Chromosome Res Date: 2004 Impact factor: 5.239

8. Isolation of a yeast centromere and construction of functional small circular chromosomes.

Authors: L Clarke; J Carbon
Journal: Nature Date: 1980-10-09 Impact factor: 49.962

9. Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore.

Authors: Emanuela Screpanti; Anna De Antoni; Gregory M Alushin; Arsen Petrovic; Tiziana Melis; Eva Nogales; Andrea Musacchio
Journal: Curr Biol Date: 2011-02-25 Impact factor: 10.834

10. Xenopus HJURP and condensin II are required for CENP-A assembly.

Authors: Rafael Bernad; Patricia Sánchez; Teresa Rivera; Miriam Rodríguez-Corsino; Ekaterina Boyarchuk; Isabelle Vassias; Dominique Ray-Gallet; Alexei Arnaoutov; Mary Dasso; Geneviève Almouzni; Ana Losada
Journal: J Cell Biol Date: 2011-02-14 Impact factor: 10.539

37 in total

1. Identification of the Post-translational Modifications Present in Centromeric Chromatin.

Authors: Aaron O Bailey; Tanya Panchenko; Jeffrey Shabanowitz; Stephanie M Lehman; Dina L Bai; Donald F Hunt; Ben E Black; Daniel R Foltz
Journal: Mol Cell Proteomics Date: 2015-12-18 Impact factor: 5.911

2. How two become one: HJURP dimerization drives CENP-A assembly.

Authors: Dani L Bodor; Lars E T Jansen
Journal: EMBO J Date: 2013-06-21 Impact factor: 11.598

3. Kinetochore function and chromosome segregation rely on critical residues in histones H3 and H4 in budding yeast.

Authors: Tessie M Ng; Tineke L Lenstra; Nicole Duggan; Shuangying Jiang; Steven Ceto; Frank C P Holstege; Junbiao Dai; Jef D Boeke; Sue Biggins
Journal: Genetics Date: 2013-09-13 Impact factor: 4.562

Review 4. Nucleosome structure and dynamics are coming of age.

Authors: Keda Zhou; Guillaume Gaullier; Karolin Luger
Journal: Nat Struct Mol Biol Date: 2018-12-10 Impact factor: 15.369

5. The ultrastructure of mono- and holocentric plant centromeres: an immunological investigation by structured illumination microscopy and scanning electron microscopy.

Authors: Gerhard Wanner; Elizabeth Schroeder-Reiter; Wei Ma; Andreas Houben; Veit Schubert
Journal: Chromosoma Date: 2015-06-06 Impact factor: 4.316