Literature DB >> 11408244

Novel mutations in ndh in isoniazid-resistant Mycobacterium tuberculosis isolates.

A S Lee1, A S Teo, S Y Wong.   

Abstract

Novel mutations in NADH dehydrogenase (ndh) were detected in 8 of 84 (9.5%) isoniazid (INH)-resistant isolates (T110A [n = 1], R268H [n = 7]), but not in 22 INH-susceptible isolates of Mycobacterium tuberculosis. Significantly, all eight isolates with mutations at ndh did not have mutations at katG, kasA, or the promoter regions of inhA or ahpC, except for one isolate. Mutations in ndh appear to be an additional molecular mechanism for isoniazid resistance in M. tuberculosis.

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Year:  2001        PMID： 11408244      PMCID： PMC90621          DOI： 10.1128/AAC.45.7.2157-2159.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Contribution of kasA analysis to detection of isoniazid-resistant Mycobacterium tuberculosis in Singapore.

Authors:  A S Lee; I H Lim; L L Tang; A Telenti; S Y Wong
Journal:  Antimicrob Agents Chemother       Date:  1999-08       Impact factor: 5.191

2.  Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis.

Authors:  B Heym; P M Alzari; N Honoré; S T Cole
Journal:  Mol Microbiol       Date:  1995-01       Impact factor: 3.501

3.  Strain identification of Mycobacterium tuberculosis by DNA fingerprinting: recommendations for a standardized methodology.

Authors:  J D van Embden; M D Cave; J T Crawford; J W Dale; K D Eisenach; B Gicquel; P Hermans; C Martin; R McAdam; T M Shinnick
Journal:  J Clin Microbiol       Date:  1993-02       Impact factor: 5.948

4.  Genotypic analysis of Mycobacterium tuberculosis in two distinct populations using molecular beacons: implications for rapid susceptibility testing.

Authors:  A S Piatek; A Telenti; M R Murray; H El-Hajj; W R Jacobs; F R Kramer; D Alland
Journal:  Antimicrob Agents Chemother       Date:  2000-01       Impact factor: 5.191

5.  High-resolution minisatellite-based typing as a portable approach to global analysis of Mycobacterium tuberculosis molecular epidemiology.

Authors:  E Mazars; S Lesjean; A L Banuls; M Gilbert; V Vincent; B Gicquel; M Tibayrenc; C Locht; P Supply
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-13       Impact factor: 11.205

6.  Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis.

Authors:  A Quémard; J C Sacchettini; A Dessen; C Vilcheze; R Bittman; W R Jacobs; J S Blanchard
Journal:  Biochemistry       Date:  1995-07-04       Impact factor: 3.162

7.  Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis.

Authors:  D A Rouse; Z Li; G H Bai; S L Morris
Journal:  Antimicrob Agents Chemother       Date:  1995-11       Impact factor: 5.191

8.  Flavin-dependent alkyl hydroperoxide reductase from Salmonella typhimurium. 1. Purification and enzymatic activities of overexpressed AhpF and AhpC proteins.

Authors:  L B Poole; H R Ellis
Journal:  Biochemistry       Date:  1996-01-09       Impact factor: 3.162

9.  Characterization of the catalase-peroxidase gene (katG) and inhA locus in isoniazid-resistant and -susceptible strains of Mycobacterium tuberculosis by automated DNA sequencing: restricted array of mutations associated with drug resistance.

Authors:  J M Musser; V Kapur; D L Williams; B N Kreiswirth; D van Soolingen; J D van Embden
Journal:  J Infect Dis       Date:  1996-01       Impact factor: 5.226

10.  Purification and characterization of the Mycobacterium smegmatis catalase-peroxidase involved in isoniazid activation.

Authors:  J A Marcinkeviciene; R S Magliozzo; J S Blanchard
Journal:  J Biol Chem       Date:  1995-09-22       Impact factor: 5.157
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  48 in total

1.  Discrimination of single-copy IS6110 DNA fingerprints of Mycobacterium tuberculosis isolates by high-resolution minisatellite-based typing.

Authors:  Ann S G Lee; Lynn L H Tang; Irene H K Lim; Richard Bellamy; Sin-Yew Wong
Journal:  J Clin Microbiol       Date:  2002-02       Impact factor: 5.948

2.  Rapid identification of mycobacteria and drug-resistant Mycobacterium tuberculosis by use of a single multiplex PCR and DNA sequencing.

Authors:  Ailyn C Pérez-Osorio; David S Boyle; Zachary K Ingham; Alla Ostash; Romesh K Gautom; Craig Colombel; Yolanda Houze; Brandon T Leader
Journal:  J Clin Microbiol       Date:  2011-12-07       Impact factor: 5.948

3.  Molecular characterization of isoniazid-resistant Mycobacterium tuberculosis clinical isolates in Lithuania.

Authors:  Daiva Bakonyte; Aurelija Baranauskaite; Jurate Cicenaite; Anaida Sosnovskaja; Petras Stakenas
Journal:  Antimicrob Agents Chemother       Date:  2003-06       Impact factor: 5.191

4.  Mutations in katG, inhA, and ahpC genes of Brazilian isoniazid-resistant isolates of Mycobacterium tuberculosis.

Authors:  Márcia Susana N Silva; Simone G Senna; Marta O Ribeiro; Andréia R M Valim; Maria Alice Telles; Afrânio Kritski; Glenn P Morlock; Robert C Cooksey; Arnaldo Zaha; Maria Lucia R Rossetti
Journal:  J Clin Microbiol       Date:  2003-09       Impact factor: 5.948

5.  Disequilibrium in distribution of resistance mutations among Mycobacterium tuberculosis Beijing and non-Beijing strains isolated from patients in Germany.

Authors:  Doris Hillemann; Tanja Kubica; Sabine Rüsch-Gerdes; Stefan Niemann
Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

6.  Detection of mutations associated with isoniazid resistance in Mycobacterium tuberculosis isolates from China.

Authors:  Min Zhang; Jun Yue; Yan-Ping Yang; Hong-Mei Zhang; Jian-Qiang Lei; Rui-Liang Jin; Xue-Lian Zhang; Hong-Hai Wang
Journal:  J Clin Microbiol       Date:  2005-11       Impact factor: 5.948

7.  High frequency of mutations in the rpoB gene in rifampin-resistant clinical isolates of Mycobacterium tuberculosis from Singapore.

Authors:  Ann S G Lee; Irene H K Lim; Lynn L H Tang; Sin Yew Wong
Journal:  J Clin Microbiol       Date:  2005-04       Impact factor: 5.948

8.  Use of genotype MTBDR assay for molecular detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis clinical strains isolated in Italy.

Authors:  Paolo Miotto; Federica Piana; Valeria Penati; Filippo Canducci; Giovanni Battista Migliori; Daniela Maria Cirillo
Journal:  J Clin Microbiol       Date:  2006-07       Impact factor: 5.948

9.  Molecular investigation of resistance to the antituberculous drug ethionamide in multidrug-resistant clinical isolates of Mycobacterium tuberculosis.

Authors:  F Brossier; N Veziris; C Truffot-Pernot; V Jarlier; W Sougakoff
Journal:  Antimicrob Agents Chemother       Date:  2010-10-25       Impact factor: 5.191

10.  An upstream truncation of the furA-katG operon confers high-level isoniazid resistance in a Mycobacterium tuberculosis clinical isolate with no known resistance-associated mutations.

Authors:  Gilman Kit Hang Siu; Wing Cheong Yam; Ying Zhang; Richard Y T Kao
Journal:  Antimicrob Agents Chemother       Date:  2014-08-04       Impact factor: 5.191
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