Literature DB >> 12958298

Mutations in katG, inhA, and ahpC genes of Brazilian isoniazid-resistant isolates of Mycobacterium tuberculosis.

Márcia Susana N Silva1, Simone G Senna, Marta O Ribeiro, Andréia R M Valim, Maria Alice Telles, Afrânio Kritski, Glenn P Morlock, Robert C Cooksey, Arnaldo Zaha, Maria Lucia R Rossetti.   

Abstract

The presence of mutations in specific regions of the katG, inhA, and ahpC genes was analyzed with 69 Mycobacterium tuberculosis isoniazid-resistant isolates from three Brazilian states. Point mutations in codon 315 of the katG gene were observed in 87.1, 60.9, and 60% of the isolates from Rio Grande do Sul, Rio de Janeiro, and São Paulo, respectively. Mutations in the inhA gene were identified only in one isolate from RJ State, and the ahpC promoter region revealed mutations in distinct positions in 12.9, 21.7, and 6.7% of the isolates from RS, RJ and SP, respectively.

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Year:  2003        PMID： 12958298      PMCID： PMC193791          DOI： 10.1128/JCM.41.9.4471-4474.2003

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


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