Literature DB >> 10428945

Contribution of kasA analysis to detection of isoniazid-resistant Mycobacterium tuberculosis in Singapore.

A S Lee1, I H Lim, L L Tang, A Telenti, S Y Wong.   

Abstract

Genotypic analysis of resistance to isoniazid (INH) in Mycobacterium tuberculosis is complex due to the various genes potentially involved. Mutations in ketoacyl acyl carrier protein synthase (encoded by kasA) were present in 16 of 160 (10%) INH-resistant isolates (R121K [n = 1], G269S [n = 3], G312S [n = 11], G387D [n = 1]). However, G312S was also present in 6 of 32 (19%) susceptible strains. kasA analysis contributed marginally to the performance of INH genotypic testing in Singapore. The significance of kasA polymorphisms in INH resistance should be carefully established.

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Year:  1999        PMID： 10428945      PMCID： PMC89423     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

Review 1.  Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update.

Authors:  S Ramaswamy; J M Musser
Journal:  Tuber Lung Dis       Date:  1998

2.  Genotypic assessment of isoniazid and rifampin resistance in Mycobacterium tuberculosis: a blind study at reference laboratory level.

Authors:  A Telenti; N Honoré; C Bernasconi; J March; A Ortega; B Heym; H E Takiff; S T Cole
Journal:  J Clin Microbiol       Date:  1997-03       Impact factor: 5.948

3.  Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis.

Authors:  D R Sherman; K Mdluli; M J Hickey; T M Arain; S L Morris; C E Barry; C K Stover
Journal:  Science       Date:  1996-06-14       Impact factor: 47.728

4.  katG mutations in isoniazid-resistant Mycobacterium tuberculosis isolates recovered from Finnish patients.

Authors:  H J Marttila; H Soini; P Huovinen; M K Viljanen
Journal:  Antimicrob Agents Chemother       Date:  1996-09       Impact factor: 5.191

5.  Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis.

Authors:  B Heym; P M Alzari; N Honoré; S T Cole
Journal:  Mol Microbiol       Date:  1995-01       Impact factor: 3.501

6.  Molecular mechanisms of multiple drug resistance in clinical isolates of Mycobacterium tuberculosis.

Authors:  S Morris; G H Bai; P Suffys; L Portillo-Gomez; M Fairchok; D Rouse
Journal:  J Infect Dis       Date:  1995-04       Impact factor: 5.226

7.  Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis.

Authors:  D A Rouse; Z Li; G H Bai; S L Morris
Journal:  Antimicrob Agents Chemother       Date:  1995-11       Impact factor: 5.191

8.  Rapid Mycobacterium species assignment and unambiguous identification of mutations associated with antimicrobial resistance in Mycobacterium tuberculosis by automated DNA sequencing.

Authors:  V Kapur; L L Li; M R Hamrick; B B Plikaytis; T M Shinnick; A Telenti; W R Jacobs; A Banerjee; S Cole; K Y Yuen
Journal:  Arch Pathol Lab Med       Date:  1995-02       Impact factor: 5.534

9.  Characterization of the catalase-peroxidase gene (katG) and inhA locus in isoniazid-resistant and -susceptible strains of Mycobacterium tuberculosis by automated DNA sequencing: restricted array of mutations associated with drug resistance.

Authors:  J M Musser; V Kapur; D L Williams; B N Kreiswirth; D van Soolingen; J D van Embden
Journal:  J Infect Dis       Date:  1996-01       Impact factor: 5.226

10.  The extreme sensitivity of Mycobacterium tuberculosis to the front-line antituberculosis drug isoniazid.

Authors:  V Deretic; E Pagán-Ramos; Y Zhang; S Dhandayuthapani; L E Via
Journal:  Nat Biotechnol       Date:  1996-11       Impact factor: 54.908
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  39 in total

1.  High prevalence of KatG Ser315Thr substitution among isoniazid-resistant Mycobacterium tuberculosis clinical isolates from northwestern Russia, 1996 to 2001.

Authors:  Igor Mokrousov; Olga Narvskaya; Tatiana Otten; Elena Limeschenko; Lidia Steklova; Boris Vyshnevskiy
Journal:  Antimicrob Agents Chemother       Date:  2002-05       Impact factor: 5.191

2.  Discrimination of single-copy IS6110 DNA fingerprints of Mycobacterium tuberculosis isolates by high-resolution minisatellite-based typing.

Authors:  Ann S G Lee; Lynn L H Tang; Irene H K Lim; Richard Bellamy; Sin-Yew Wong
Journal:  J Clin Microbiol       Date:  2002-02       Impact factor: 5.948

3.  Molecular characterization of isoniazid-resistant Mycobacterium tuberculosis clinical isolates in Lithuania.

Authors:  Daiva Bakonyte; Aurelija Baranauskaite; Jurate Cicenaite; Anaida Sosnovskaja; Petras Stakenas
Journal:  Antimicrob Agents Chemother       Date:  2003-06       Impact factor: 5.191

4.  Mutations in katG, inhA, and ahpC genes of Brazilian isoniazid-resistant isolates of Mycobacterium tuberculosis.

Authors:  Márcia Susana N Silva; Simone G Senna; Marta O Ribeiro; Andréia R M Valim; Maria Alice Telles; Afrânio Kritski; Glenn P Morlock; Robert C Cooksey; Arnaldo Zaha; Maria Lucia R Rossetti
Journal:  J Clin Microbiol       Date:  2003-09       Impact factor: 5.948

5.  Screening and characterization of mutations in isoniazid-resistant Mycobacterium tuberculosis isolates obtained in Brazil.

Authors:  Rosilene Fressatti Cardoso; Robert C Cooksey; Glenn P Morlock; Patricia Barco; Leticia Cecon; Francisco Forestiero; Clarice Q F Leite; Daisy N Sato; Maria de Lourdes Shikama; Elsa M Mamizuka; Rosario D C Hirata; Mario H Hirata
Journal:  Antimicrob Agents Chemother       Date:  2004-09       Impact factor: 5.191

6.  Detection of mutations associated with isoniazid resistance in Mycobacterium tuberculosis isolates from China.

Authors:  Min Zhang; Jun Yue; Yan-Ping Yang; Hong-Mei Zhang; Jian-Qiang Lei; Rui-Liang Jin; Xue-Lian Zhang; Hong-Hai Wang
Journal:  J Clin Microbiol       Date:  2005-11       Impact factor: 5.948

7.  High frequency of mutations in the rpoB gene in rifampin-resistant clinical isolates of Mycobacterium tuberculosis from Singapore.

Authors:  Ann S G Lee; Irene H K Lim; Lynn L H Tang; Sin Yew Wong
Journal:  J Clin Microbiol       Date:  2005-04       Impact factor: 5.948

8.  Novel mutations within the embB gene in ethambutol-susceptible clinical isolates of Mycobacterium tuberculosis.

Authors:  Ann S G Lee; Siti Noor Khadijah Othman; Yu Min Ho; Sin Yew Wong
Journal:  Antimicrob Agents Chemother       Date:  2004-11       Impact factor: 5.191

9.  New multiplex PCR for rapid detection of isoniazid-resistant Mycobacterium tuberculosis clinical isolates.

Authors:  Laura Herrera-León; Tamara Molina; Pilar Saíz; Juan Antonio Sáez-Nieto; Maria Soledad Jiménez
Journal:  Antimicrob Agents Chemother       Date:  2005-01       Impact factor: 5.191

10.  Biological and molecular characteristics of Mycobacterium tuberculosis clinical isolates with low-level resistance to isoniazid in Japan.

Authors:  Chiyoji Abe; Ikuo Kobayashi; Satoshi Mitarai; Masako Wada; Yoshiko Kawabe; Tetsuya Takashima; Katsuhiro Suzuki; Li-Hwei Sng; Suxing Wang; Hla Hla Htay; Hideo Ogata
Journal:  J Clin Microbiol       Date:  2008-05-28       Impact factor: 5.948
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