Literature DB >> 11331904

The flexible genome.

R J Greenspan.   

Abstract

A principal assumption underlying contemporary genetic analysis is that the normal function of a gene can be inferred directly from its mutant phenotype. The interactivity among genes that is now being revealed calls this assumption into question and indicates that there might be considerable flexibility in the capacity of the genome to respond to diverse conditions. The reservoir for much of this flexibility resides in the nonspecificity and malleability of gene action.

Mesh:

Year:  2001        PMID: 11331904     DOI: 10.1038/35072018

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN: 1471-0056            Impact factor:   53.242


  46 in total

1.  Extensive phenotypic variation in early flowering mutants of Arabidopsis.

Authors:  Sylvie Pouteau; Valérie Ferret; Valérie Gaudin; Delphine Lefebvre; Mohammed Sabar; Gengchun Zhao; Franck Prunus
Journal:  Plant Physiol       Date:  2004-04-30       Impact factor: 8.340

2.  Biological indeterminacy.

Authors:  Ralph J Greenspan
Journal:  Sci Eng Ethics       Date:  2012-07-03       Impact factor: 3.525

3.  Messy biology and the origins of evolutionary innovations.

Authors:  Dan S Tawfik
Journal:  Nat Chem Biol       Date:  2010-10       Impact factor: 15.040

4.  Expert performance in sport and the dynamics of talent development.

Authors:  Elissa Phillips; Keith Davids; Ian Renshaw; Marc Portus
Journal:  Sports Med       Date:  2010-04-01       Impact factor: 11.136

5.  Homology and ontogeny: pattern and process in comparative developmental biology.

Authors:  Gerhard Scholtz
Journal:  Theory Biosci       Date:  2005-09-23       Impact factor: 1.919

Review 6.  Complexities and uncertainties of neuronal network function.

Authors:  David Parker
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2006-01-29       Impact factor: 6.237

7.  Microarray analysis of replicate populations selected against a wing-shape correlation in Drosophila melanogaster.

Authors:  Kenneth E Weber; Ralph J Greenspan; David R Chicoine; Katia Fiorentino; Mary H Thomas; Theresa L Knight
Journal:  Genetics       Date:  2008-02-01       Impact factor: 4.562

8.  Quantitative genetic analysis of sleep in Drosophila melanogaster.

Authors:  Susan T Harbison; Amita Sehgal
Journal:  Genetics       Date:  2008-04       Impact factor: 4.562

Review 9.  Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems.

Authors:  Patrick C Phillips
Journal:  Nat Rev Genet       Date:  2008-11       Impact factor: 53.242

10.  The Drosophila foraging gene mediates adult plasticity and gene-environment interactions in behaviour, metabolites, and gene expression in response to food deprivation.

Authors:  Clement F Kent; Tim Daskalchuk; Lisa Cook; Marla B Sokolowski; Ralph J Greenspan
Journal:  PLoS Genet       Date:  2009-08-21       Impact factor: 5.917

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