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Literature DB >> 18852697

Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems.

Abstract

Epistasis, or interactions between genes, has long been recognized as fundamentally important to understanding the structure and function of genetic pathways and the evolutionary dynamics of complex genetic systems. With the advent of high-throughput functional genomics and the emergence of systems approaches to biology, as well as a new-found ability to pursue the genetic basis of evolution down to specific molecular changes, there is a renewed appreciation both for the importance of studying gene interactions and for addressing these questions in a unified, quantitative manner.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Year: 2008 PMID： 18852697 PMCID： PMC2689140 DOI： 10.1038/nrg2452

Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242

93 in total

Review 1. Principles for the buffering of genetic variation.

Authors: J L Hartman; B Garvik; L Hartwell
Journal: Science Date: 2001-02-09 Impact factor: 47.728

Review 2. Ordering gene function: the interpretation of epistasis in regulatory hierarchies.

Authors: L Avery; S Wasserman
Journal: Trends Genet Date: 1992-09 Impact factor: 11.639

Review 3. Mapping complex disease loci in whole-genome association studies.

Authors: Christopher S Carlson; Michael A Eberle; Leonid Kruglyak; Deborah A Nickerson
Journal: Nature Date: 2004-05-27 Impact factor: 49.962

4. Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction.

Authors: Chia-Ti Tsai; Juey-Jen Hwang; Marylyn D Ritchie; Jason H Moore; Fu-Tien Chiang; Ling-Ping Lai; Kuan-Lih Hsu; Chuen-Den Tseng; Jiunn-Lee Lin; Yung-Zu Tseng
Journal: Atherosclerosis Date: 2006-11-21 Impact factor: 5.162

5. Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions.

Authors: Robert P St Onge; Ramamurthy Mani; Julia Oh; Michael Proctor; Eula Fung; Ronald W Davis; Corey Nislow; Frederick P Roth; Guri Giaever
Journal: Nat Genet Date: 2007-01-07 Impact factor: 38.330

6. The frailty of adaptive hypotheses for the origins of organismal complexity.

Authors: Michael Lynch
Journal: Proc Natl Acad Sci U S A Date: 2007-05-09 Impact factor: 11.205

7. Crystal structure of an ancient protein: evolution by conformational epistasis.

Authors: Eric A Ortlund; Jamie T Bridgham; Matthew R Redinbo; Joseph W Thornton
Journal: Science Date: 2007-08-16 Impact factor: 47.728

8. Modular epistasis in yeast metabolism.

Authors: Daniel Segrè; Alexander Deluna; George M Church; Roy Kishony
Journal: Nat Genet Date: 2004-12-12 Impact factor: 38.330

9. Both additivity and epistasis control the genetic variation for fruit quality traits in tomato.

Authors: Mathilde Causse; Jamila Chaïb; Laurent Lecomte; Michel Buret; Frédéric Hospital
Journal: Theor Appl Genet Date: 2007-06-15 Impact factor: 5.574

10. Adaptive variation in beach mice produced by two interacting pigmentation genes.

Authors: Cynthia C Steiner; Jesse N Weber; Hopi E Hoekstra
Journal: PLoS Biol Date: 2007-09 Impact factor: 8.029

582 in total

1. X-autosome incompatibilities in Drosophila melanogaster: tests of Haldane's rule and geographic patterns within species.

Authors: Joseph Lachance; John R True
Journal: Evolution Date: 2010-08-19 Impact factor: 3.694

10. Genetic regulatory network motifs constrain adaptation through curvature in the landscape of mutational (co)variance.

Authors: Tyler D Hether; Paul A Hohenlohe
Journal: Evolution Date: 2013-12-04 Impact factor: 3.694

Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems.

Review 1. Principles for the buffering of genetic variation.

Review 2. Ordering gene function: the interpretation of epistasis in regulatory hierarchies.

Review 3. Mapping complex disease loci in whole-genome association studies.

4. Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction.

5. Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions.

6. The frailty of adaptive hypotheses for the origins of organismal complexity.

7. Crystal structure of an ancient protein: evolution by conformational epistasis.

8. Modular epistasis in yeast metabolism.

9. Both additivity and epistasis control the genetic variation for fruit quality traits in tomato.

10. Adaptive variation in beach mice produced by two interacting pigmentation genes.

1. X-autosome incompatibilities in Drosophila melanogaster: tests of Haldane's rule and geographic patterns within species.

2. Diminishing returns epistasis among beneficial mutations decelerates adaptation.

3. Sequence variation in the herpes simplex virus U(S)1 ocular virulence determinant.

4. Epistasis can lead to fragmented neutral spaces and contingency in evolution.

5. Detecting genome-wide epistases based on the clustering of relatively frequent items.

6. Magnitude and sign epistasis among deleterious mutations in a positive-sense plant RNA virus.

7. Coalitional game theory as a promising approach to identify candidate autism genes.

8. Minimum epistasis interpolation for sequence-function relationships.

Review 9. Decanalizing thinking on genetic canalization.

10. Genetic regulatory network motifs constrain adaptation through curvature in the landscape of mutational (co)variance.