| Literature DB >> 1127382 |
V A Lennon, J M Lindstrom, M E Seybold.
Abstract
Immunization of animals with acetylcholine receptor (AChR) protein from the electric organs of Electrophorus electricus and Torpedo californica induces an autoimmune response to the AChR of mammalian skeletal muscle. Rats and guinea pigs develop experimental autoimmune myasthenia gravis (EAMG) after a single inoculation with small quantities of AChR and adjuvant. The indicence and severity of disease appears to depend on the dose of AChR and stability of the emulsion. EAMG is strikingly similar to myasthenia gravis (MG) of man in its clinical picture and its electrophysiological abnormalities. The presence of antibodies to syngeneic rat muscle AChR in the serum of rats with EAMG documents the existence of autoimmunity in the experimental disease. A common immunopathogenesis is suggested for both EAMG and mg.Entities:
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Year: 1975 PMID： 1127382 PMCID： PMC2189842 DOI： 10.1084/jem.141.6.1365
Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307