Literature DB >> 4742736

Neuromuscular junction in myasthenia gravis: decreased acetylcholine receptors.

D M Fambrough, D B Drachman, S Satyamurti.   

Abstract

The number of acetylcholine receptors was determined in the neuromuscular junctions of eight patients with typical myasthenia gravis and in five controls, by means of (125)1-labeled alpha-bungarotoxin binding. The junctional acetylcholine receptors were reduced in the myasthenic muscles as compared with the controls. This reduction in receptors may account for the defect in neuromuscular transmission in myasthenia gravis.

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Year:  1973        PMID： 4742736     DOI： 10.1126/science.182.4109.293

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  103 in total

Review 1.  Neurochemistry and behavior in man.

Authors:  G S Omenn
Journal:  West J Med       Date:  1976-12

Review 2.  Desensitization of the nicotinic acetylcholine receptor: molecular mechanisms and effect of modulators.

Authors:  E L Ochoa; A Chattopadhyay; M G McNamee
Journal:  Cell Mol Neurobiol       Date:  1989-06       Impact factor: 5.046

3.  Modeling of twitch fade based on slow interaction of nondepolarizing muscle relaxants with the presynaptic receptors.

Authors:  Shashi B Bhatt; Anton Amann; Vladimir Nigrovic
Journal:  J Pharmacokinet Pharmacodyn       Date:  2006-06-03       Impact factor: 2.745

4.  Effects of chronic treatment with various neuromuscular blocking agents on the number and distribution of acetylcholine receptors in the rat diaphragm.

Authors:  C C Chang; S T Chuang; M C Huang
Journal:  J Physiol       Date:  1975-08       Impact factor: 5.182

5.  A cholinoceptor antiserum: its pharmacological properties.

Authors:  F Berti; F Clementi; B Conti-Tronconi; G C Folco
Journal:  Br J Pharmacol       Date:  1976-05       Impact factor: 8.739

6.  Cellular immune response to acetylcholine receptor-rich fraction, in patients with myasthenia gravis.

Authors:  O Abramsky; A Aharonov; C Webb; S Fuchs
Journal:  Clin Exp Immunol       Date:  1975-01       Impact factor: 4.330

7.  Inhibition mechanism of the acetylcholine receptor by alpha-neurotoxins as revealed by normal-mode dynamics.

Authors:  Abraham O Samson; Michael Levitt
Journal:  Biochemistry       Date:  2008-03-08       Impact factor: 3.162

8.  Impairment of T lymphocyte functions in mice with motor end-plate disease.

Authors:  M Papiernik; F Rieger; S Ezine; M Pincon-Raymond
Journal:  Clin Exp Immunol       Date:  1982-05       Impact factor: 4.330

9.  Subpopulations of T lymphocytes in myasthenia gravis patients.

Authors:  M Piantelli; L Lauriola; A Carbone; A Evoli; P Tonali; P Musiani
Journal:  Clin Exp Immunol       Date:  1979-04       Impact factor: 4.330

10.  Absence of anti-acetylcholine receptor antibodies in Praomys (Mastomys) natalensis.

Authors:  A Vincent; H A Solleveld
Journal:  Clin Exp Immunol       Date:  1981-01       Impact factor: 4.330
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