Literature DB >> 4706680

Autoimmune response to acetylcholine receptor.

J Patrick, J Lindstrom.   

Abstract

Injection of rabbits with acetylcholine receptor highly purified from the electric organ of Electrophorus electricus emulsified in complete Freund's adjuvant resulted in the production of precipitating antibody to acetylcholine receptor. After the second injection of antigen, the animals developed the flaccid paralysis and abnormal electromyographs characteristic of neuromuscular blockade. Treatment with the anticholinesterases edrophonium or neostigmine dramatically alleviated the paralysis and the fatigue seen in electromyography.

Entities:  

Mesh：

Substances：

Year:  1973        PMID： 4706680     DOI： 10.1126/science.180.4088.871

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  175 in total

1.  Treatment of passively transferred experimental autoimmune myasthenia gravis using papain.

Authors:  K Poulas; T Tsouloufis; S J Tzartos
Journal:  Clin Exp Immunol       Date:  2000-05       Impact factor: 4.330

2.  Myasthenia gravis and the thymus gland.

Authors: 
Journal:  West J Med       Date:  1975-08

Review 3.  Intrathymic expression of neuromuscular acetylcholine receptors and the immunpathogenesis of myasthenia gravis.

Authors:  Arnold I Levinson; Yi Zheng; Glen Gaulton; Decheng Song; Jonni Moore; C Hank Pletcher
Journal:  Immunol Res       Date:  2003       Impact factor: 2.829

Review 4.  Immunohistochemistry of cholinergic receptors.

Authors:  H Schröder
Journal:  Anat Embryol (Berl)       Date:  1992-10

5.  A model of the closed form of the nicotinic acetylcholine receptor m2 channel pore.

Authors:  Sanguk Kim; Aaron K Chamberlain; James U Bowie
Journal:  Biophys J       Date:  2004-08       Impact factor: 4.033

6.  Specific immunotherapy of experimental myasthenia gravis by a novel mechanism.

Authors:  Jie Luo; Alexander Kuryatov; Jon M Lindstrom
Journal:  Ann Neurol       Date:  2010-04       Impact factor: 10.422

7.  Myasthenogenicity of the main immunogenic region and endogenous muscle nicotinic acetylcholine receptors.

Authors:  Jie Luo; Jon Lindstrom
Journal:  Autoimmunity       Date:  2011-10-21       Impact factor: 2.815

Review 8.  Desensitization of the nicotinic acetylcholine receptor: molecular mechanisms and effect of modulators.

Authors:  E L Ochoa; A Chattopadhyay; M G McNamee
Journal:  Cell Mol Neurobiol       Date:  1989-06       Impact factor: 5.046

Review 9.  Myasthenia gravis--current concepts.

Authors:  C Herrmann; J M Lindstrom; J C Keesey; D G Mulder
Journal:  West J Med       Date:  1985-06

10.  Lymphocyte subpopulations and surface membrane immunoglobulins in myasthenia gravis.

Authors:  G Landi; M Galli; G Ciboddo; G Colombo; G Scarlato
Journal:  J Neurol Neurosurg Psychiatry       Date:  1982-02       Impact factor: 10.154
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.