Literature DB >> 11243453

Polyhydroxylated alkaloids -- natural occurrence and therapeutic applications.

A A Watson1, G W Fleet, N Asano, R J Molyneux, R J Nash.   

Abstract

Over one hundred polyhydroxylated alkaloids have been isolated from plants and micro-organisms. These alkaloids can be potent and highly selective glycosidase inhibitors and are arousing great interest as tools to study cellular recognition and as potential therapeutic agents. However, only three of the natural products so far have been widely studied for therapeutic potential due largely to the limited commercial availability of the other compounds.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11243453     DOI： 10.1016/s0031-9422(00)00451-9

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  54 in total

Review 1.  The good and the bad of poisonous plants: an introduction to the USDA-ARS Poisonous Plant Research Laboratory.

Authors:  Kevin D Welch; Kip E Panter; Dale R Gardner; Bryan L Stegelmeier
Journal:  J Med Toxicol       Date:  2012-06

2.  5-(4-Fluoro-benzyl-idene)-4'-(4-fluoro-phen-yl)-1,1'-dimethyl-dispiro-[piperidine-3,3'-pyrrolidine-2',3''-indoline]-4,2''-dione.

Authors:  V Rajni Swamy; S Ramaswamy; N Srinivasan; R Ranjith Kumar; R V Krishnakumar
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-09-05

3.  Synthetic N-alkylated iminosugars as new potential immunosuppressive agents.

Authors:  Guan-Nan Wang; Yulan Xiong; Jia Ye; Li-He Zhang; Xin-Shan Ye
Journal:  ACS Med Chem Lett       Date:  2011-07-05       Impact factor: 4.345

4.  Distinguishing the differences in β-glycosylceramidase folds, dynamics, and actions informs therapeutic uses.

Authors:  Fredj Ben Bdira; Marta Artola; Herman S Overkleeft; Marcellus Ubbink; Johannes M F G Aerts
Journal:  J Lipid Res       Date:  2018-10-02       Impact factor: 5.922

Review 5.  Glycosidase inhibition: assessing mimicry of the transition state.

Authors:  Tracey M Gloster; Gideon J Davies
Journal:  Org Biomol Chem       Date:  2009-11-05       Impact factor: 3.876

6.  5''-(4-Chloro-benzyl-idene)-1',1''-dimethyl-3'-phenyl-acenaphthene-1-spiro-2'-pyrrolidine-3'-spiro-3''-pyridine-2,4''-dione.

Authors:  S Pandiarajan; S N Saravanamoorthy; B Ravi Kumar; R Ranjith Kumar; S Athimoolam
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2007-12-06

7.  2-Acetamido-N-benzyl-1,4-imino-1,2,4-tride-oxy-l-xylitol (N-benzyl-l-XYLNAc).

Authors:  Sarah F Jenkinson; Elizabeth V Crabtree; Andreas F G Glawar; Terry D Butters; George W J Fleet; David J Watkin
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-04-24

8.  Steviamine, a new class of indolizidine alkaloid [(1R,2S,3R,5R,8aR)-3-hydroxy-meth-yl-5-methyl-octa-hydro-indolizine-1,2-diol hydro-bromide].

Authors:  Amber L Thompson; Agnieszka Michalik; Robert J Nash; Francis X Wilson; Renate van Well; Peter Johnson; George W J Fleet; Chu-Yi Yu; Xiang-Guo Hu; Richard I Cooper; David J Watkin
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-10-28

9.  (4S,5R,6R)-Methyl 4-hydr-oxy-4,5-iso-propyl-idenedioxy-4,5,6,7-tetra-hydro-1,2,3-triazolo[1,5-a]pyridine-3-carboxyl-ate.

Authors:  Sarah F Jenkinson; Jennifer R Fenton; K Victoria Booth; George W J Fleet; David J Watkin
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-02-25

10.  4'-(2,4-Dichloro-phen-yl)-1,1'-dimethyl-piperidine-3-spiro-3'-pyrrolidine-2'-spiro-3''-indoline-4,2''-dione.

Authors:  S Nagamuthu; R Sribala; R Ranjithkumar; R V Krishnakumar; N Srinivasan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-02-27
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.