Literature DB >> 23125644

5-(4-Fluoro-benzyl-idene)-4'-(4-fluoro-phen-yl)-1,1'-dimethyl-dispiro-[piperidine-3,3'-pyrrolidine-2',3''-indoline]-4,2''-dione.

V Rajni Swamy1, S Ramaswamy, N Srinivasan, R Ranjith Kumar, R V Krishnakumar.   

Abstract

The asymmetric unit of the title compound, C(30)H(27)F(2)N(3)O(2), contains two independent mol-ecules. The pyrrolidine five-membered ring assumes an envelope conformation (with the CH(2) atom at the flap) in one mol-ecule and a twisted conformation in the other one. In both independent mol-ecules, the 4-piperidinone rings adopt a similar twisted chair conformation. In the crystal, the two independent mol-ecules form an R(2) (2)(8) dimer through a pair of N-H⋯O hydrogen bonds; the R(2) (2)(8) dimers are connected via weak C-H⋯O hydrogen bonds, leading to a chain extending along the c axis.

Entities:  

Year:  2012        PMID: 23125644      PMCID: PMC3470200          DOI: 10.1107/S1600536812037245

Source DB:  PubMed          Journal:  Acta Crystallogr Sect E Struct Rep Online        ISSN: 1600-5368


  4 in total

Review 1.  Polyhydroxylated alkaloids -- natural occurrence and therapeutic applications.

Authors:  A A Watson; G W Fleet; N Asano; R J Molyneux; R J Nash
Journal:  Phytochemistry       Date:  2001-02       Impact factor: 4.072

2.  A short history of SHELX.

Authors:  George M Sheldrick
Journal:  Acta Crystallogr A       Date:  2007-12-21       Impact factor: 2.290

3.  A new route to spirooxindoles.

Authors:  S T Hilton; T C Ho; G Pljevaljcic; K Jones
Journal:  Org Lett       Date:  2000-08-24       Impact factor: 6.005

4.  Imidazole derivatives of pyrrolidonic and piperidonic as potential inhibitors of human placental aromatase in vitro.

Authors:  M Baroudi; J Robert; C Luu-Duc
Journal:  J Steroid Biochem Mol Biol       Date:  1996-01       Impact factor: 4.292

  4 in total

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