Literature DB >> 11133071

2-Aryl tryptamines: selective high-affinity antagonists for the h5-HT2A receptor.

G I Stevenson1, A L Smith, S Lewis, S G Michie, J G Neduvelil, S Patel, R Marwood, S Patel, J L Castro.   

Abstract

A series of 2-aryl tryptamines have been identified as high-affinity h5-HT2A antagonists. Structure-activity relationship studies have shown that h5-HT2A affinity can be attained via modifications to the tryptamine side chain and that selectivity over h5-HT2C and hD2 receptors can be controlled by suitable C-2 aryl groups.

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Year:  2000        PMID： 11133071     DOI： 10.1016/s0960-894x(00)00557-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  21 in total

1.  Receptor binding profiles and behavioral pharmacology of ring-substituted N,N-diallyltryptamine analogs.

Authors:  Landon M Klein; Nicholas V Cozzi; Paul F Daley; Simon D Brandt; Adam L Halberstadt
Journal:  Neuropharmacology       Date:  2018-02-27       Impact factor: 5.250

2.  2-(1H-indol-3-ylcarbon-yl)acetonitrile.

Authors:  P Ramesh; A Subbiahpandi; P Thirumurugan; Paramasivan T Perumal; M N Ponnuswamy
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-02-04

3.  3'-Benz-yloxy-3-hydr-oxy-3,3'-bi-1H-indole-2,2'(3H,3'H)-dione monohydrate.

Authors:  P Ramesh; S S Sundaresan; N Vidhya Lakshmi; Paramasivan T Perumal; M N Ponnuswamy
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-04-08

4.  3-(4-Fluoro-phenyl)-1-[1'-(4-fluoro-phenyl)-2-oxo-5',6',7',7a'-tetra-hydro-1H-indole-3(2H)-spiro-3'(2'H)-1H'-pyrrol-izin-2'-yl]prop-2-en-1-one.

Authors:  S Nirmala; R Murugan; E Theboral Sugi Kamala; L Sudha; S Sriman Narayanan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-08-16

5.  4-(2,4-Dichlorophenyl)-2-(1H-indol-3-yl)-6-(2-pyridyl)-1,4-dihydropyridine-4-carbonitrile.

Authors:  P Ramesh; A Subbiahpandi; P Thirumurugan; Paramasivan T Perumal; M N Ponnuswamy
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-09-06

6.  4-(2,4-Dichloro-phen-yl)-6-(1H-indol-3-yl)-2,2'-bipyridine-5-carbonitrile.

Authors:  P Ramesh; S S Sundaresan; P Thirumurugan; Paramasivan T Perumal; M N Ponnuswamy
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-04-08

7.  1'-Methyl-2,2''-dioxoindoline-3-spiro-2'-pyrrolidine-3'-spiro-3''-indoline-4',4'-di-carbonitrile.

Authors:  P Ramesh; S S Sundaresan; N Vidhya Lakshmi; Paramasivan T Perumal; M N Ponnuswamy
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-07-22

8.  Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation.

Authors:  Scott P Runyon; Philip D Mosier; Bryan L Roth; Richard A Glennon; Richard B Westkaemper
Journal:  J Med Chem       Date:  2008-10-11       Impact factor: 7.446

9.  A facile, mild and efficient one-pot synthesis of 2-substituted indole derivatives catalyzed by Pd(PPh3)2Cl2.

Authors:  Hossien A Oskooie; Majid M Heravi; Farahnaz K Behbahani
Journal:  Molecules       Date:  2007-06-19       Impact factor: 4.411

10.  1'-Butyl-2-methyl-1',2,2',3,4,9-hexa-hydro-spiro-[benzo[f]isoindole-1,3'-indole]-2',4,9-trione.

Authors:  G Jagadeesan; K Sethusankar; G Bhaskar; P T Perumal
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-06-20
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