G E Grande1, C J Todd, S I Barclay, M C Farquhar. 1. Health Services Research Group, General Practice and Primary Care Research Unit, Department of Community Medicine, University of Cambridge, Institute of Public Health, Cambridge CB2 2SR. gag1001@medschl.cam.ac.uk
Abstract
OBJECTIVE: To evaluate the impact on place of death of a hospital at home service for palliative care. DESIGN: Pragmatic randomised controlled trial. SETTING: Former Cambridge health district. PARTICIPANTS: 229 patients referred to the hospital at home service; 43 randomised to control group (standard care), 186 randomised to hospital at home. INTERVENTION: Hospital at home versus standard care. MAIN OUTCOME MEASURES: Place of death. RESULTS:Twenty five (58%) control patients died at home compared with 124 (67%) patients allocated to hospital at home. This difference was not significant; intention to treat analysis did not show that hospital at home increased the number of deaths at home. Seventy three patients randomised to hospital at home were not admitted to the service. Patients admitted to hospital at home were significantly more likely to die at home (88/113; 78%) than control patients. It is not possible to determine whether this was due to hospital at home itself or other characteristics of the patients admitted to the service. The study attained less statistical power than initially planned. CONCLUSION: In a locality with good provision of standard community care we could not show that hospital at home allowed more patients to die at home, although neither does the study refute this. Problems relating to recruitment, attrition, and the vulnerability of the patient group make randomised controlled trials in palliative care difficult. While these difficulties have to be recognised they are not insurmountable with the appropriate resourcing and setting.
RCT Entities:
OBJECTIVE: To evaluate the impact on place of death of a hospital at home service for palliative care. DESIGN: Pragmatic randomised controlled trial. SETTING: Former Cambridge health district. PARTICIPANTS: 229 patients referred to the hospital at home service; 43 randomised to control group (standard care), 186 randomised to hospital at home. INTERVENTION: Hospital at home versus standard care. MAIN OUTCOME MEASURES: Place of death. RESULTS: Twenty five (58%) control patients died at home compared with 124 (67%) patients allocated to hospital at home. This difference was not significant; intention to treat analysis did not show that hospital at home increased the number of deaths at home. Seventy three patients randomised to hospital at home were not admitted to the service. Patients admitted to hospital at home were significantly more likely to die at home (88/113; 78%) than control patients. It is not possible to determine whether this was due to hospital at home itself or other characteristics of the patients admitted to the service. The study attained less statistical power than initially planned. CONCLUSION: In a locality with good provision of standard community care we could not show that hospital at home allowed more patients to die at home, although neither does the study refute this. Problems relating to recruitment, attrition, and the vulnerability of the patient group make randomised controlled trials in palliative care difficult. While these difficulties have to be recognised they are not insurmountable with the appropriate resourcing and setting.
Authors: Dio Kavalieratos; Jennifer Corbelli; Di Zhang; J Nicholas Dionne-Odom; Natalie C Ernecoff; Janel Hanmer; Zachariah P Hoydich; Dara Z Ikejiani; Michele Klein-Fedyshin; Camilla Zimmermann; Sally C Morton; Robert M Arnold; Lucas Heller; Yael Schenker Journal: JAMA Date: 2016-11-22 Impact factor: 56.272
Authors: Natalie C Ernecoff; Devon Check; Megan Bannon; Laura C Hanson; James Nicholas Dionne-Odom; Jennifer Corbelli; Michele Klein-Fedyshin; Yael Schenker; Camilla Zimmermann; Robert M Arnold; Dio Kavalieratos Journal: J Palliat Med Date: 2019-10-23 Impact factor: 2.947
Authors: Sally Moore; Jessica Corner; Jo Haviland; Mary Wells; Emma Salmon; Charles Normand; Mike Brada; Mary O'Brien; Ian Smith Journal: BMJ Date: 2002-11-16