Literature DB >> 10464231

Acetate utilization in Lactococcus lactis deficient in lactate dehydrogenase: a rescue pathway for maintaining redox balance.

P Hols1, A Ramos, J Hugenholtz, J Delcour, W M de Vos, H Santos, M Kleerebezem.   

Abstract

Acetate was shown to improve glucose fermentation in Lactococcus lactis deficient in lactate dehydrogenase. 13C and 1H nuclear magnetic resonance studies using [2-13C]glucose and [2-(13)C]acetate as substrates demonstrated that acetate was exclusively converted to ethanol. This novel pathway provides an alternative route for NAD+ regeneration in the absence of lactate dehydrogenase.

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Year:  1999        PMID： 10464231      PMCID： PMC94066     

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  18 in total

1.  Citrate Fermentation by Lactococcus and Leuconostoc spp.

Authors:  M J Starrenburg; J Hugenholtz
Journal:  Appl Environ Microbiol       Date:  1991-12       Impact factor: 4.792

Review 2.  Metabolic engineering of sugar catabolism in lactic acid bacteria.

Authors:  W M de Vos
Journal:  Antonie Van Leeuwenhoek       Date:  1996-10       Impact factor: 2.271

3.  Cloning, sequence analysis, and functional expression of the acetyl coenzyme A synthetase gene from Methanothrix soehngenii in Escherichia coli.

Authors:  R I Eggen; A C Geerling; A B Boshoven; W M de Vos
Journal:  J Bacteriol       Date:  1991-10       Impact factor: 3.490

4.  Conversion of Lactococcus lactis from homolactic to homoalanine fermentation through metabolic engineering.

Authors:  P Hols; M Kleerebezem; A N Schanck; T Ferain; J Hugenholtz; J Delcour; W M de Vos
Journal:  Nat Biotechnol       Date:  1999-06       Impact factor: 54.908

5.  Acetaldehyde: an intermediate in the formation of ethanol from glucose by lactic acid bacteria.

Authors:  G J Lees
Journal:  J Dairy Res       Date:  1976-02       Impact factor: 1.904

6.  Cloning of the Lactococcus lactis adhE gene, encoding a multifunctional alcohol dehydrogenase, by complementation of a fermentative mutant of Escherichia coli.

Authors:  J Arnau; F Jørgensen; S M Madsen; A Vrang; H Israelsen
Journal:  J Bacteriol       Date:  1998-06       Impact factor: 3.490

7.  Citrate and Sugar Cofermentation in Leuconostoc oenos, a (sup13)C Nuclear Magnetic Resonance Study.

Authors:  A Ramos; H Santos
Journal:  Appl Environ Microbiol       Date:  1996-07       Impact factor: 4.792

8.  Cofactor engineering: a novel approach to metabolic engineering in Lactococcus lactis by controlled expression of NADH oxidase.

Authors:  F Lopez de Felipe; M Kleerebezem; W M de Vos; J Hugenholtz
Journal:  J Bacteriol       Date:  1998-08       Impact factor: 3.490

9.  Identification of genes involved in utilization of acetate and acetoin in Bacillus subtilis.

Authors:  F J Grundy; D A Waters; T Y Takova; T M Henkin
Journal:  Mol Microbiol       Date:  1993-10       Impact factor: 3.501

10.  Effect of acetate on sorbitol fermentation by oral lactobacilli.

Authors:  N Takahashi; S Kalfas; T Yamada
Journal:  Oral Microbiol Immunol       Date:  1995-12
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  16 in total

Review 1.  Microbial cellulose utilization: fundamentals and biotechnology.

Authors:  Lee R Lynd; Paul J Weimer; Willem H van Zyl; Isak S Pretorius
Journal:  Microbiol Mol Biol Rev       Date:  2002-09       Impact factor: 11.056

2.  Effect of different NADH oxidase levels on glucose metabolism by Lactococcus lactis: kinetics of intracellular metabolite pools determined by in vivo nuclear magnetic resonance.

Authors:  Ana Rute Neves; Ana Ramos; Helena Costa; Iris I van Swam; Jeroen Hugenholtz; Michiel Kleerebezem; Willem de Vos; Helena Santos
Journal:  Appl Environ Microbiol       Date:  2002-12       Impact factor: 4.792

3.  High-level production of the low-calorie sugar sorbitol by Lactobacillus plantarum through metabolic engineering.

Authors:  Victor Ladero; Ana Ramos; Anne Wiersma; Philippe Goffin; André Schanck; Michiel Kleerebezem; Jeroen Hugenholtz; Eddy J Smid; Pascal Hols
Journal:  Appl Environ Microbiol       Date:  2007-01-19       Impact factor: 4.792

4.  High-level acetaldehyde production in Lactococcus lactis by metabolic engineering.

Authors:  Roger S Bongers; Marcel H N Hoefnagel; Michiel Kleerebezem
Journal:  Appl Environ Microbiol       Date:  2005-02       Impact factor: 4.792

5.  IS981-mediated adaptive evolution recovers lactate production by ldhB transcription activation in a lactate dehydrogenase-deficient strain of Lactococcus lactis.

Authors:  Roger S Bongers; Marcel H N Hoefnagel; Marjo J C Starrenburg; Marco A J Siemerink; John G A Arends; Jeroen Hugenholtz; Michiel Kleerebezem
Journal:  J Bacteriol       Date:  2003-08       Impact factor: 3.490

6.  Engineering Lactococcus lactis for production of mannitol: high yields from food-grade strains deficient in lactate dehydrogenase and the mannitol transport system.

Authors:  Paula Gaspar; Ana Rute Neves; Ana Ramos; Michael J Gasson; Claire A Shearman; Helena Santos
Journal:  Appl Environ Microbiol       Date:  2004-03       Impact factor: 4.792

7.  Glucose metabolism in Lactococcus lactis MG1363 under different aeration conditions: requirement of acetate to sustain growth under microaerobic conditions.

Authors:  Mikkel Nordkvist; Niels Bang Siemsen Jensen; John Villadsen
Journal:  Appl Environ Microbiol       Date:  2003-06       Impact factor: 4.792

Review 8.  Metabolic shifts: a fitness perspective for microbial cell factories.

Authors:  Anisha Goel; Meike Tessa Wortel; Douwe Molenaar; Bas Teusink
Journal:  Biotechnol Lett       Date:  2012-08-31       Impact factor: 2.461

9.  Transcriptomes reveal genetic signatures underlying physiological variations imposed by different fermentation conditions in Lactobacillus plantarum.

Authors:  Peter A Bron; Michiel Wels; Roger S Bongers; Hermien van Bokhorst-van de Veen; Anne Wiersma; Lex Overmars; Maria L Marco; Michiel Kleerebezem
Journal:  PLoS One       Date:  2012-07-03       Impact factor: 3.240

10.  Oxygen relieves the CO2 and acetate dependency of Lactobacillus johnsonii NCC 533.

Authors:  Rosanne Y Hertzberger; R David Pridmore; Christof Gysler; Michiel Kleerebezem; M Joost Teixeira de Mattos
Journal:  PLoS One       Date:  2013-02-26       Impact factor: 3.240
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