Literature DB >> 9925549

Expression in Escherichia coli of a new multidrug efflux pump, MexXY, from Pseudomonas aeruginosa.

T Mine1, Y Morita, A Kataoka, T Mizushima, T Tsuchiya.   

Abstract

Two new genes (mexXY) similar to mexAB, mexCD, and mexEF and mediating multidrug resistance were cloned from the chromosome of Pseudomonas aeruginosa. Elevated ethidium extrusion was observed with Escherichia coli cells harboring the plasmid carrying mexXY. This MexXY system confers higher resistance to fluoroquinolones than the MexAB and MexCD systems, and E. coli ToIC or P. aeruginosa OprM is necessary for the function of the MexXY system.

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Year:  1999        PMID： 9925549      PMCID： PMC89094     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  25 in total

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Authors:  K I BERNS; C A THOMAS
Journal:  J Mol Biol       Date:  1965-03       Impact factor: 5.469

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Journal:  Virology       Date:  1955-07       Impact factor: 3.616

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Authors:  K Nakamura; M Inouye
Journal:  Cell       Date:  1979-12       Impact factor: 41.582

4.  A single amino acid determinant of the membrane localization of lipoproteins in E. coli.

Authors:  K Yamaguchi; F Yu; M Inouye
Journal:  Cell       Date:  1988-05-06       Impact factor: 41.582

5.  Efflux pumps and drug resistance in gram-negative bacteria.

Authors:  D Ma; D N Cook; J E Hearst; H Nikaido
Journal:  Trends Microbiol       Date:  1994-12       Impact factor: 17.079

6.  Physical and genetical analysis of bacteriophage T4 generalized transduction.

Authors:  K K Young; G Edlin
Journal:  Mol Gen Genet       Date:  1983

7.  Analysis of membrane and surface protein sequences with the hydrophobic moment plot.

Authors:  D Eisenberg; E Schwarz; M Komaromy; R Wall
Journal:  J Mol Biol       Date:  1984-10-15       Impact factor: 5.469

8.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

9.  Studies on transformation of Escherichia coli with plasmids.

Authors:  D Hanahan
Journal:  J Mol Biol       Date:  1983-06-05       Impact factor: 5.469

10.  Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli.

Authors:  D Ma; D N Cook; M Alberti; N G Pon; H Nikaido; J E Hearst
Journal:  Mol Microbiol       Date:  1995-04       Impact factor: 3.501
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  110 in total

1.  Hypersusceptibility of the Pseudomonas aeruginosa nfxB mutant to beta-lactams due to reduced expression of the ampC beta-lactamase.

Authors:  N Masuda; E Sakagawa; S Ohya; N Gotoh; T Nishino
Journal:  Antimicrob Agents Chemother       Date:  2001-04       Impact factor: 5.191

2.  Insertion mutagenesis and membrane topology model of the Pseudomonas aeruginosa outer membrane protein OprM.

Authors:  K K Wong; R E Hancock
Journal:  J Bacteriol       Date:  2000-05       Impact factor: 3.490

3.  Influence of mutations in the mexR repressor gene on expression of the MexA-MexB-oprM multidrug efflux system of Pseudomonas aeruginosa.

Authors:  R Srikumar; C J Paul; K Poole
Journal:  J Bacteriol       Date:  2000-03       Impact factor: 3.490

4.  Evaluation of a structural model of Pseudomonas aeruginosa outer membrane protein OprM, an efflux component involved in intrinsic antibiotic resistance.

Authors:  K K Wong; F S Brinkman; R S Benz; R E Hancock
Journal:  J Bacteriol       Date:  2001-01       Impact factor: 3.490

Review 5.  Molecular properties of bacterial multidrug transporters.

Authors:  M Putman; H W van Veen; W N Konings
Journal:  Microbiol Mol Biol Rev       Date:  2000-12       Impact factor: 11.056

6.  Resistance-nodulation-cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454.

Authors:  S Magnet; P Courvalin; T Lambert
Journal:  Antimicrob Agents Chemother       Date:  2001-12       Impact factor: 5.191

7.  Expression of multidrug efflux pump SmeDEF by clinical isolates of Stenotrophomonas maltophilia.

Authors:  A Alonso; J L Martinez
Journal:  Antimicrob Agents Chemother       Date:  2001-06       Impact factor: 5.191

Review 8.  Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria.

Authors:  K Poole
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

9.  Multidrug efflux pumps: expression patterns and contribution to antibiotic resistance in Pseudomonas aeruginosa biofilms.

Authors:  T R De Kievit; M D Parkins; R J Gillis; R Srikumar; H Ceri; K Poole; B H Iglewski; D G Storey
Journal:  Antimicrob Agents Chemother       Date:  2001-06       Impact factor: 5.191

10.  Contribution of resistance-nodulation-division efflux pump operon smeU1-V-W-U2-X to multidrug resistance of Stenotrophomonas maltophilia.

Authors:  Chao-Hsien Chen; Chiang-Ching Huang; Tsao-Chuen Chung; Rouh-Mei Hu; Yi-Wei Huang; Tsuey-Ching Yang
Journal:  Antimicrob Agents Chemother       Date:  2011-09-19       Impact factor: 5.191
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