Literature DB >> 11257048

Hypersusceptibility of the Pseudomonas aeruginosa nfxB mutant to beta-lactams due to reduced expression of the ampC beta-lactamase.

N Masuda1, E Sakagawa, S Ohya, N Gotoh, T Nishino.   

Abstract

The Pseudomonas aeruginosa nfxB mutant lacking mexAB-oprM showed hypersusceptibility to 9 out of 24 beta-lactams tested. This hypersusceptibility was found for the nfxB mutant lacking mexAB-oprM-mexXY (N108) but not for the nfxB mutant lacking both mexAB-oprM-mexXY and ampC. The level of the AmpC beta-lactamase induction was reduced in N108. Thus, the reduced AmpC induction must be the cause of the hypersusceptibility.

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Year:  2001        PMID： 11257048      PMCID： PMC90457          DOI： 10.1128/AAC.45.4.1284-1286.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

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Journal:  Antimicrob Agents Chemother       Date:  1992-09       Impact factor: 5.191

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Review 3.  Regulation of inducible AmpC beta-lactamase expression among Enterobacteriaceae.

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Journal:  Curr Pharm Des       Date:  1999-11       Impact factor: 3.116

4.  Characterization of a Pseudomonas aeruginosa efflux pump contributing to aminoglycoside impermeability.

Authors:  S Westbrock-Wadman; D R Sherman; M J Hickey; S N Coulter; Y Q Zhu; P Warrener; L Y Nguyen; R M Shawar; K R Folger; C K Stover
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5.  In vitro and in vivo activities of Syn2190, a novel beta-lactamase inhibitor.

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Journal:  Antimicrob Agents Chemother       Date:  1999-08       Impact factor: 5.191

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Authors:  N Masuda; E Sakagawa; S Ohya; N Gotoh; H Tsujimoto; T Nishino
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Authors:  N Masuda; E Sakagawa; S Ohya; N Gotoh; H Tsujimoto; T Nishino
Journal:  Antimicrob Agents Chemother       Date:  2000-12       Impact factor: 5.191

8.  Investigation of the Pseudomonas aeruginosa ampR gene and its role at the chromosomal ampC beta-lactamase promoter.

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Journal:  FEMS Microbiol Lett       Date:  1993-08-01       Impact factor: 2.742

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Review 4.  Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.

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5.  A large-scale whole-genome comparison shows that experimental evolution in response to antibiotics predicts changes in naturally evolved clinical Pseudomonas aeruginosa.

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6.  SmeC, an outer membrane multidrug efflux protein of Stenotrophomonas maltophilia.

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7.  Antagonistic interactions of Pseudomonas aeruginosa antibiotic resistance mechanisms in planktonic but not biofilm growth.

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8.  Pseudomonas aeruginosa PAO1 adapted to 2-phenoxyethanol shows cross-resistance to dissimilar biocides and increased susceptibility to antibiotics.

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Review 10.  Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms.

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