| Literature DB >> 9873531 |
A J Souers1, A A Virgilio, S S Schürer, J A Ellman, T P Kogan, H E West, W Ankener, P Vanderslice.
Abstract
A library of 2302 small molecule beta-turn mimetics was screened for inhibition of the alpha 4 beta 1 integrin-CS1 splice variant binding interaction. Preliminary data revealed several active ligands, and validation with purified material culminated in the identification of some of the first small molecule ligands (1, IC50 = 5 microM, and 2, IC50 = 8 microM) to be reported for this class of integrins.Mesh：
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Year: 1998 PMID： 9873531 DOI： 10.1016/s0960-894x(98)00416-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823