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Literature DB >> 18343129

A road less traveled by: exploring a decade of Ellman chemistry.

Abstract

The Ellman group has been one of the most influential in the development and widespread adoption of combinatorial chemistry techniques for biomedical research. Their work has included substantial methodological development for library synthesis with a particular focus on new scaffolds rationally targeted to biomolecules of interest and biologically relevant natural products. Herein we analyze a representative set of libraries from this group with respect to their biological and biomedical relevance in comparison to existing drugs and probe compounds. This analysis reveals that the Ellman group has not only provided new methodologies to the community but also provided libraries with unique potential for further biological study.

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Year: 2008 PMID： 18343129 PMCID： PMC2663904 DOI： 10.1016/j.bmc.2008.02.087

Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641

23 in total

Review 1. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.

Authors: C A Lipinski; F Lombardo; B W Dominy; P J Feeney
Journal: Adv Drug Deliv Rev Date: 2001-03-01 Impact factor: 15.470

2. Combinatorial target-guided ligand assembly: identification of potent subtype-selective c-Src inhibitors.

Authors: D J Maly; I C Choong; J A Ellman
Journal: Proc Natl Acad Sci U S A Date: 2000-03-14 Impact factor: 11.205

3. Use of biomimetic diversity-oriented synthesis to discover galanthamine-like molecules with biological properties beyond those of the natural product.

Authors: H E Pelish; N J Westwood; Y Feng; T Kirchhausen; M D Shair
Journal: J Am Chem Soc Date: 2001-07-11 Impact factor: 15.419

A road less traveled by: exploring a decade of Ellman chemistry.

Review 1. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.

2. Combinatorial target-guided ligand assembly: identification of potent subtype-selective c-Src inhibitors.

3. Use of biomimetic diversity-oriented synthesis to discover galanthamine-like molecules with biological properties beyond those of the natural product.

4. A 'rule of three' for fragment-based lead discovery?

5. A synthesis strategy yielding skeletally diverse small molecules combinatorially.

6. Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery.

Review 7. The interdependence between screening methods and screening libraries.

8. A new type of synthetic peptide library for identifying ligand-binding activity.

9. The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library.

10. Synthesis of a diverse library of mechanism-based cysteine protease inhibitors.

Review 1. Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.