Literature DB >> 18329275

A small molecule inhibitor of alpha4 integrin-dependent cell migration.

Jongkook Lee1, Jiyong Hong, Tae-Gyu Nam, Eric C Peters, Anthony P Orth, Bernhard H Geierstanger, Lawrence E Goldfinger, Mark H Ginsberg, Charles Y Cho, Peter G Schultz.   

Abstract

A small molecule inhibitor of alpha4 integrin-dependent cell migration was identified through a cell-based screen of small molecule libraries. Biochemical and cellular experiments suggest that this molecule functions by interacting with gamma-parvin. This molecule should serve as a useful tool to study alpha4 integrin signaling and may lead to new therapeutics for the treatment of autoimmune diseases.

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Year:  2008        PMID： 18329275      PMCID： PMC2951142          DOI： 10.1016/j.bmc.2008.02.067

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  18 in total

1.  A combinatorial scaffold approach toward kinase-directed heterocycle libraries.

Authors:  Sheng Ding; Nathanael S Gray; Xu Wu; Qiang Ding; Peter G Schultz
Journal:  J Am Chem Soc       Date:  2002-02-27       Impact factor: 15.419

Review 2.  T-cell function and migration. Two sides of the same coin.

Authors:  U H von Andrian; C R Mackay
Journal:  N Engl J Med       Date:  2000-10-05       Impact factor: 91.245

3.  Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.

Authors:  D Y Jackson; C Quan; D R Artis; T Rawson; B Blackburn; M Struble; G Fitzgerald; K Chan; S Mullins; J P Burnier; W J Fairbrother; K Clark; M Berisini; H Chui; M Renz; S Jones; S Fong
Journal:  J Med Chem       Date:  1997-10-10       Impact factor: 7.446

4.  Activation pathways of alpha4beta1 integrin leading to distinct T-cell cytoskeleton reorganization, Rac1 regulation and Pyk2 phosphorylation.

Authors:  Alfredo Maqueda; José V Moyano; M Dolores Gutiérrez-López; Susana Ovalle; José M Rodríguez-Frade; Carlos Cabañas; Angeles Garcia-Pardo
Journal:  J Cell Physiol       Date:  2006-06       Impact factor: 6.384

5.  Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin alpha 4 beta 7.

Authors:  P E Hesterberg; D Winsor-Hines; M J Briskin; D Soler-Ferran; C Merrill; C R Mackay; W Newman; D J Ringler
Journal:  Gastroenterology       Date:  1996-11       Impact factor: 22.682

6.  Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses.

Authors:  S Liu; S M Thomas; D G Woodside; D M Rose; W B Kiosses; M Pfaff; M H Ginsberg
Journal:  Nature       Date:  1999-12-09       Impact factor: 49.962

7.  Attenuation of colitis in the cotton-top tamarin by anti-alpha 4 integrin monoclonal antibody.

Authors:  D K Podolsky; R Lobb; N King; C D Benjamin; B Pepinsky; P Sehgal; M deBeaumont
Journal:  J Clin Invest       Date:  1993-07       Impact factor: 14.808

8.  Inhibitors of cell migration that inhibit intracellular paxillin/alpha4 binding: a well-documented use of positional scanning libraries.

Authors:  Yves Ambroise; Brian Yaspan; Mark H Ginsberg; Dale L Boger
Journal:  Chem Biol       Date:  2002-11

Review 9.  Alpha 4 integrin antagonists.

Authors:  David Y Jackson
Journal:  Curr Pharm Des       Date:  2002       Impact factor: 3.116

10.  A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods.

Authors:  Justin C Yarrow; Zachary E Perlman; Nicholas J Westwood; Timothy J Mitchison
Journal:  BMC Biotechnol       Date:  2004-09-09       Impact factor: 2.563
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  3 in total

Review 1.  Phenotypic screening in cancer drug discovery - past, present and future.

Authors:  John G Moffat; Joachim Rudolph; David Bailey
Journal:  Nat Rev Drug Discov       Date:  2014-07-18       Impact factor: 84.694

2.  Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin.

Authors:  Colleen Ring; Mark H Ginsberg; Jacob Haling; Ann Marie Pendergast
Journal:  Proc Natl Acad Sci U S A       Date:  2010-12-20       Impact factor: 11.205

Review 3.  Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma.

Authors:  Ruixia Huang; Einar K Rofstad
Journal:  J Exp Clin Cancer Res       Date:  2018-04-27
  3 in total

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