Literature DB >> 11865647

Combinatorial approaches to inhibitors of VLA-4: piperazine-peptoid-bisarylureas.

I Lewis1, B Rohde, M Mengus, M Weetall, S Maida, R Hugo, P Lake.   

Abstract

A combinatorial approach towards identifying inhibitors of VALA-4 was investigated. A library of piperazine-peptoid-bisarylureas was assembled in solid phase and screening in the novel v-well assay enabled the identification of active compounds.

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Year:  2000        PMID： 11865647     DOI： 10.1023/a:1013990624215

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  19 in total

1.  Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.

Authors:  T A Yednock; C Cannon; L C Fritz; F Sanchez-Madrid; L Steinman; N Karin
Journal:  Nature       Date:  1992-03-05       Impact factor: 49.962

Review 2.  VLA proteins in the integrin family: structures, functions, and their role on leukocytes.

Authors:  M E Hemler
Journal:  Annu Rev Immunol       Date:  1990       Impact factor: 28.527

Review 3.  Application of combinatorial library methods in cancer research and drug discovery.

Authors:  K S Lam
Journal:  Anticancer Drug Des       Date:  1997-04

Review 4.  Anti-integrin immunotherapy in rheumatoid arthritis: protective effect of anti-alpha 4 antibody in adjuvant arthritis.

Authors:  C Barbadillo; A G-Arroyo; C Salas; J Mulero; F Sánchez-Madrid; J L Andreu
Journal:  Springer Semin Immunopathol       Date:  1995

5.  Combinatorial chemistry reveals a new motif that binds the platelet fibrinogen receptor, gpIIbIIIa.

Authors:  D S Thorpe; H Yeoman; A W Chan; V Krchnak; M Lebl; S Felder
Journal:  Biochem Biophys Res Commun       Date:  1999-03-24       Impact factor: 3.575

6.  Imide and lactam derivatives of N-benzylpyroglutamyl-L-phenylalanine as VCAM/VLA-4 antagonists.

Authors:  J W Tilley; G Kaplan; K Rowan; V Schwinge; B Wolitzky
Journal:  Bioorg Med Chem Lett       Date:  2001-01-08       Impact factor: 2.823

7.  A cyclic hexapeptide is a potent antagonist of alpha 4 integrins.

Authors:  P Vanderslice; K Ren; J K Revelle; D C Kim; D Scott; R J Bjercke; E T Yeh; P J Beck; T P Kogan
Journal:  J Immunol       Date:  1997-02-15       Impact factor: 5.422

8.  The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine.

Authors:  A Komoriya; L J Green; M Mervic; S S Yamada; K M Yamada; M J Humphries
Journal:  J Biol Chem       Date:  1991-08-15       Impact factor: 5.157

9.  Blockade of very late antigen-4 integrin binding to fibronectin with connecting segment-1 peptide reduces accelerated coronary arteriopathy in rabbit cardiac allografts.

Authors:  S Molossi; M Elices; T Arrhenius; R Diaz; C Coulber; M Rabinovitch
Journal:  J Clin Invest       Date:  1995-06       Impact factor: 14.808

10.  Immunosuppression to cardiac allografts and soluble antigens by anti-vascular cellular adhesion molecule-1 and anti-very late antigen-4 monoclonal antibodies.

Authors:  M Isobe; J Suzuki; H Yagita; K Okumura; S Yamazaki; R Nagai; Y Yazaki; M Sekiguchi
Journal:  J Immunol       Date:  1994-12-15       Impact factor: 5.422
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  1 in total

1.  Brønsted acid-mediated cyclization-dehydrosulfonylation/reduction sequences: An easy access to pyrazinoisoquinolines and pyridopyrazines.

Authors:  Ramana Sreenivasa Rao; Chinnasamy Ramaraj Ramanathan
Journal:  Beilstein J Org Chem       Date:  2017-03-07       Impact factor: 2.883
  1 in total

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