Literature DB >> 985456

Binding of diethylstilboestrol to deoxyribonucleic acid by rat liver microsomal fractions in vitro and in mouse foetal cells in culture.

G M Blackburn, M H Thompson, H W King.   

Abstract

Diethylstillboestrol, a synthetic and carcinogenic hormone, binds to DNA as a result of incubation with a liver microsomal preparation in vitro and on incubation with primary mouse foetal cells in culture. Enzymic digestion of DNA samples thus prepared gives several covalent deoxyribonucleoside-diethylstilboestrol products from the microsomal system. One of these is produced in small but significant yield in the tissue-culture system.

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Year:  1976        PMID： 985456      PMCID： PMC1164021          DOI： 10.1042/bj1580643

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  16 in total

1.  Comparison of the cellular DNA-bound products of benzo(alpha)pyrene with the products formed by the reaction of benzo(alpha)pyrene-4,5-oxide with DNA.

Authors:  W M Baird; R G Harvey; P Brookes
Journal:  Cancer Res       Date:  1975-01       Impact factor: 12.701

2.  ISOLATION AND CHARACTERIZATION OF RIBOSOMAL RIBONUCLEIC ACID.

Authors:  K S KIRBY
Journal:  Biochem J       Date:  1965-07       Impact factor: 3.857

3.  Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.

Authors:  J McCann; E Choi; E Yamasaki; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1975-12       Impact factor: 11.205

4.  [Hypophyseal tumors produced by diethylstilbestrol].

Authors:  E FELS
Journal:  C R Seances Soc Biol Fil       Date:  1950-09

Review 5.  Estrogen-receptor interaction.

Authors:  E V Jensen; E R DeSombre
Journal:  Science       Date:  1973-10-12       Impact factor: 47.728

6.  The use of estrogen antagonists in hormone receptor studies.

Authors:  E V Jensen; H I Jacobson; S Smith; P W Jungblut; E R De Sombre
Journal:  Gynecol Invest       Date:  1972

7.  Oxidative and photochemical linkage of diethylstilbestrol to DNA in vitro.

Authors:  G M Blackburn; A J Flavell; M H Thompson
Journal:  Cancer Res       Date:  1974-08       Impact factor: 12.701

8.  Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women.

Authors:  A L Herbst; H Ulfelder; D C Poskanzer
Journal:  N Engl J Med       Date:  1971-04-15       Impact factor: 91.245

9.  A microsome-dependent binding of benzo[a]pyrene to DNA.

Authors:  H V Gelboin
Journal:  Cancer Res       Date:  1969-06       Impact factor: 12.701

Review 10.  Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion.

Authors:  J McCann; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1976-03       Impact factor: 11.205
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  6 in total

Review 1.  DNA adducts of medicinal drugs: some selected examples.

Authors:  M Metzler
Journal:  J Cancer Res Clin Oncol       Date:  1986       Impact factor: 4.553

Review 2.  Metabolism of stilbene estrogens and steroidal estrogens in relation to carcinogenicity.

Authors:  M Metzler
Journal:  Arch Toxicol       Date:  1984-07       Impact factor: 5.153

3.  Metabolic activation of diethylstilbestrol and aminostilbene-derivatives.

Authors:  H G Neumann; M Metzler; W Töpner
Journal:  Arch Toxicol       Date:  1977-12-30       Impact factor: 5.153

4.  The binding of steroid hormones and diethylstilbestrol to proteins of human cells in culture.

Authors:  M Murakami; J Fukami
Journal:  Arch Toxicol       Date:  1983-07       Impact factor: 5.153

5.  Metabolism of [14C]diethylstilboestrol epoxide by rat liver in vitro.

Authors:  P H Jellinck; J H Bowen
Journal:  Biochem J       Date:  1980-01-01       Impact factor: 3.857

6.  Quantitative predictability of carcinogenicity of the covalent binding index of chemicals to DNA: comparison of the in vivo and in vitro assays.

Authors:  M Taningher; G Saccomanno; L Santi; S Grilli; S Parodi
Journal:  Environ Health Perspect       Date:  1990-03       Impact factor: 9.031
  6 in total

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